product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse N-Cadherin Fc Chimera Protein, CF
catalog :
6626-NC-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Burmeister M, Frauenstein A, Kahms M, Arends L, Gerwien H, Deshpande T, et al. Secretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function. Sci Adv. 2023;9:eadg0686 pubmed publisher
Shoykhet M, Dervishi O, Menauer P, Hiermaier M, Moztarzadeh S, Osterloh C, et al. EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation. JCI Insight. 2023;8: pubmed publisher
Joy Immediato M, Ramirez M, Cerda M, Toyama Y, Ravasio A, Kanchanawong P, et al. Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions. Front Cell Dev Biol. 2021;9:669086 pubmed publisher
Pak J, DeLoughery Z, Wang J, Acharya N, Park Y, Jaworski A, et al. NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance. Nat Commun. 2020;11:1489 pubmed publisher
Silva C, Peyre E, Adhikari M, Tielens S, Tanco S, Van Damme P, et al. Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Cell. 2018;172:1063-1078.e19 pubmed publisher
Libé Philippot B, Michel V, Boutet de Monvel J, Le Gal S, Dupont T, Avan P, et al. Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction. Proc Natl Acad Sci U S A. 2017;114:7765-7774 pubmed publisher
Conant K, Daniele S, Bozzelli P, Abdi T, Edwards A, Szklarczyk A, et al. Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation. J Neuroinflammation. 2017;14:56 pubmed publisher
Matsunaga Y, Noda M, Murakawa H, Hayashi K, Nagasaka A, Inoue S, et al. Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development. Proc Natl Acad Sci U S A. 2017;114:2048-2053 pubmed publisher
Bertocchi C, Wang Y, Ravasio A, Hara Y, Wu Y, Sailov T, et al. Nanoscale architecture of cadherin-based cell adhesions. Nat Cell Biol. 2017;19:28-37 pubmed publisher
Wiertz R, Marani E, Rutten W. Neural cell-cell and cell-substrate adhesion through N-cadherin, N-CAM and L1. J Neural Eng. 2011;8:046004 pubmed publisher
product information
master code :
6626-NC
SKU :
6626-NC-050
product name :
Recombinant Mouse N-Cadherin Fc Chimera Protein, CF
unit size :
50 ug
description :
The Recombinant Mouse N-Cadherin Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse N-Cadherin Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
N-Cadherin
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
observed molecular weight :
(115-120) kDa (130-135) kDa, reducing conditions
theoretical molecular weight :
88.8 kDa (monomer, mature protein) 104.2 kDa (monomer, pro-protein)
gene symbol :
Cdh2
details of functionality :
Measured by the ability of the immobilized protein to support the adhesion of U-118-MG human glioblastoma/astrocytoma cells. The ED50 for this effect is 0.1-0.5 ╡g/mL.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
NP_031690
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived mouse N-Cadherin protein Mouse N-Cadherin (Met1 - Ala724) Accession # NP_031690 IEGRMDP Mouse IgG2A (Glu98 - Lys330) N-terminus C-terminus
source short :
NS0
USD :
432 USD
alt names :
ACOGS, ARVD14, cadherin 2, type 1, N-cadherin (neuronal), cadherin-2, calcium-dependent adhesion protein, neuronal, CD325, CD325 antigen, CDH2, CDHN, CDw325, NCAD, N-cadherin, NCadherin, N-cadherin 1, Neural cadherin, neural-cadherin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.