Recombinant Human Agrin Protein, CF | R&D Systems 6624-AG-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Agrin Protein, CF

catalog :

6624-AG-050

quantity :

50 ug

price :

499 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Yamashita Y, Nakada S, Nakamura K, Sakurai H, Ohno K, Goto T, et al. Evaluation of Human-Induced Pluripotent Stem Cells Derived from a Patient with Schwartz-Jampel Syndrome Revealed Distinct Hyperexcitability in the Skeletal Muscles. Biomedicines. 2023;11: pubmed publisher
Stoklund Dittlau K, Terrie L, Baatsen P, Kerstens A, De Swert L, Janky R, et al. FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms. Mol Neurodegener. 2023;18:5 pubmed publisher
Pandya M, Gopinathan G, Tillberg C, Wang J, Luan X, Diekwisch T. The Hippo Pathway Effectors YAP/TAZ Are Essential for Mineralized Tissue Homeostasis in the Alveolar Bone/Periodontal Complex. J Dev Biol. 2022;10: pubmed publisher
Stoklund Dittlau K, Krasnow E, Fumagalli L, Vandoorne T, Baatsen P, Kerstens A, et al. Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition. Stem Cell Reports. 2021;16:2213-2227 pubmed publisher
Lin C, Yoshida M, Li L, Ikenaka A, Oshima S, Nakagawa K, et al. iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases. JCI Insight. 2019;4: pubmed publisher
Nagy N, Barad C, Hotta R, Bhave S, Arciero E, DORA D, et al. Collagen 18 and agrin are secreted by neural crest cells to remodel their microenvironment and regulate their migration during enteric nervous system development. Development. 2018;145: pubmed publisher
Katt M, Linville R, Mayo L, Xu Z, Searson P. Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation. Fluids Barriers CNS. 2018;15:7 pubmed publisher
Toda M, Ueno M, Yamada J, Hiraga A, Tanaka H, Schlötzer Schrehardt U, et al. The Different Binding Properties of Cultured Human Corneal Endothelial Cell Subpopulations to Descemet's Membrane Components. Invest Ophthalmol Vis Sci. 2016;57:4599-605 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

6624-AG

SKU :

6624-AG-050

product name :

Recombinant Human Agrin Protein, CF

Description :

The Recombinant Human Agrin Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Agrin Protein, CF has been validated for the following applications: Bioactivity.

target :

Agrin

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

100-110 kDa, reducing conditions

theoretical molecular weight :

83.5 kDa

gene symbol :

AGRN

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of U-87 MG human glioblastoma/astrocytoma cells. The typical ED50 for this effect is 0.9-3.6 µg/mL after 1 hour incubation at 37 °C. . Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_940978

applications :

Bioactivity

source :

CHO-derived Recombinant Human Agrin Protein

USD :

499 USD

alt names :

agrin, agrin proteoglycan, AGRN

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage