Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein, CF | R&D Systems 661-FR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein, CF

catalog :

661-FR

quantity :

50 ug

price :

339 USD

citations: 9

Reference
Rasmussen K, Falkesgaard M, Winther M, Roed N, Quistgaard C, Teisen M, et al. NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor. Sci Rep. 2018;8:8957 pubmed publisher
Shi S, Lu Y, Liu Z, Stevens J, Murawsky C, Wilson V, et al. A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity. J Biol Chem. 2018;293:5909-5919 pubmed publisher
Yang L, Hansen Falkesgaard M, Thulstrup P, Walmod P, Lo Leggio L, Krighaar Rasmussen K. Expression, refolding and spectroscopic characterization of fibronectin type III (FnIII)-homology domains derived from human fibronectin leucine rich transmembrane protein (FLRT)-1, -2, and -3. Peerj. 2017;5:e3550 pubmed publisher
Lelliott C, Ahnmark A, Admyre T, Ahlstedt I, Irving L, Keyes F, et al. Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms. PLoS ONE. 2014;9:e112109 pubmed publisher
Tao J, Xiang J, Li D, Deng N, Wang H, Gong Y. Selection and characterization of a human neutralizing antibody to human fibroblast growth factor-2. Biochem Biophys Res Commun. 2010;394:767-73 pubmed publisher
Nakayama T, Mutsuga N, Tosato G. FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. Blood. 2007;109:1363-72 pubmed
Murase S, McKay R. A specific survival response in dopamine neurons at most risk in Parkinson's disease. J Neurosci. 2006;26:9750-60 pubmed
Steinberg Z, Myers C, Heim V, Lathrop C, Rebustini I, Stewart J, et al. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development. 2005;132:1223-34 pubmed
Kessaris N, Jamen F, Rubin L, Richardson W. Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development. 2004;131:1289-98 pubmed

product information

brand :

R&D Systems

master code :

661-FR

SKU :

661-FR-050

product name :

Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein, CF

description :

The Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

FGFR1 beta

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

90-95 kDa, reducing conditions

theoretical molecular weight :

56 kDa (monomer)

gene symbol :

FGFR1

details of functionality :

Measured by its ability to inhibit FGF acidic-dependent proliferation of NR6R-3T3 mouse fibroblast cells. The ED50 for this effect is 1-3 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

661-FR

accessionNumbers :

NP_075594

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human FGF R1 beta protein Human FGF R1 beta (IIIc) (Arg22-Glu285) Accession # NP_075594 IEGRDMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

2020 USD :

339

2021 USD :

339 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.