product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein, CF
catalog :
661-FR-050
quantity :
50 ug
price :
377 USD
more info or order :
citations: 9
Reference
Rasmussen K, Falkesgaard M, Winther M, Roed N, Quistgaard C, Teisen M, et al. NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor. Sci Rep. 2018;8:8957 pubmed publisher
Shi S, Lu Y, Liu Z, Stevens J, Murawsky C, Wilson V, et al. A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity. J Biol Chem. 2018;293:5909-5919 pubmed publisher
Yang L, Hansen Falkesgaard M, Thulstrup P, Walmod P, Lo Leggio L, Krighaar Rasmussen K. Expression, refolding and spectroscopic characterization of fibronectin type III (FnIII)-homology domains derived from human fibronectin leucine rich transmembrane protein (FLRT)-1, -2, and -3. Peerj. 2017;5:e3550 pubmed publisher
Lelliott C, Ahnmark A, Admyre T, Ahlstedt I, Irving L, Keyes F, et al. Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms. PLoS ONE. 2014;9:e112109 pubmed publisher
Tao J, Xiang J, Li D, Deng N, Wang H, Gong Y. Selection and characterization of a human neutralizing antibody to human fibroblast growth factor-2. Biochem Biophys Res Commun. 2010;394:767-73 pubmed publisher
Nakayama T, Mutsuga N, Tosato G. FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. Blood. 2007;109:1363-72 pubmed
Murase S, McKay R. A specific survival response in dopamine neurons at most risk in Parkinson's disease. J Neurosci. 2006;26:9750-60 pubmed
Steinberg Z, Myers C, Heim V, Lathrop C, Rebustini I, Stewart J, et al. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development. 2005;132:1223-34 pubmed
Kessaris N, Jamen F, Rubin L, Richardson W. Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development. 2004;131:1289-98 pubmed
image
image 1 :
R&D Systems 661-FR-050 image 1
Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein Bioactivity
product information
brand :
R&D Systems
master code :
661-FR
SKU :
661-FR-050
product name :
Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein, CF
description :
The Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
FGFR1 beta
category :
Proteins and Enzymes
unit sizes :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
90-95 kDa, reducing conditions
theoretical molecular weight :
56 kDa (monomer)
gene symbol :
FGFR1
details of functionality :
Measured by its ability to inhibit FGF acidic-dependent proliferation of NR6R-3T3 mouse fibroblast cells. The ED50 for this effect is 1-3 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_075594
applications :
Bioactivity
source :
NS0-derived Recombinant Human FGFR1 beta (IIIc) Fc Chimera Protein, CF
USD :
377 USD
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.