Recombinant Human Activin B Protein, CF | R&D Systems 659-AB-005/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Activin B Protein, CF

catalog :

659-AB-005/CF

quantity :

5 ug (also 25 ug)

price :

318 USD

citations: 19

Reference
Reader K, John McHaffie S, Zellhuber McMillan S, Jowett T, Mottershead D, Cunliffe H, et al. Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth. Cancers (Basel). 2022;15: pubmed publisher
Brulé E, Wang Y, Li Y, Lin Y, Zhou X, Ongaro L, et al. TGFBR3L is an inhibin B co-receptor that regulates female fertility. Sci Adv. 2021;7:eabl4391 pubmed publisher
Hagg A, Kharoud S, Goodchild G, Goodman C, Chen J, Thomson R, et al. TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass. Front Physiol. 2020;11:560225 pubmed publisher
Olsen O, Hella H, Elsaadi S, Jacobi C, Martinez Hackert E, Holien T. Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors. Biomolecules. 2020;10: pubmed publisher
Tengroth L, Arebro J, Larsson O, Bachert C, Georén S, Cardell L. Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps. Sci Rep. 2018;8:1561 pubmed publisher
Kita A, Kasamatsu A, Nakashima D, Endo Sakamoto Y, Ishida S, Shimizu T, et al. Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis. J Cancer. 2017;8:2033-2041 pubmed publisher
Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, et al. Activin A more prominently regulates muscle mass in primates than does GDF8. Nat Commun. 2017;8:15153 pubmed publisher
Kanamori Y, Murakami M, Sugiyama M, Hashimoto O, Matsui T, Funaba M. Interleukin-1? (IL-1?) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein ? (C/EBP?) expression in hepatocytes. J Biol Chem. 2017;292:10275-10287 pubmed publisher
Stephens C, Johnson P. Occludin expression and regulation in small follicles of the layer and broiler breeder hen. Gen Comp Endocrinol. 2017;248:106-113 pubmed publisher
Kanamori Y, Sugiyama M, Hashimoto O, Murakami M, Matsui T, Funaba M. Regulation of hepcidin expression by inflammation-induced activin B. Sci Rep. 2016;6:38702 pubmed publisher
Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El Sayed K, et al. Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-Î². PLoS ONE. 2015;10:e0118097 pubmed publisher
Tamminen J, Yin M, RÃ¶nty M, Sutinen E, Pasternack A, Ritvos O, et al. Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. Exp Cell Res. 2015;332:102-15 pubmed publisher
Carrancio S, Markovics J, Wong P, Leisten J, Castiglioni P, Groza M, et al. An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin. Br J Haematol. 2014;165:870-82 pubmed publisher
Kadaja M, Keyes B, Lin M, Pasolli H, Genander M, Polak L, et al. SOX9: a stem cell transcriptional regulator of secreted niche signaling factors. Genes Dev. 2014;28:328-41 pubmed publisher
Mottershead D, Ritter L, Gilchrist R. Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15. Mol Hum Reprod. 2012;18:121-8 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Watanabe K, Hamada S, Bianco C, Mancino M, Nagaoka T, Gonzales M, et al. Requirement of glycosylphosphatidylinositol anchor of Cripto-1 for trans activity as a Nodal co-receptor. J Biol Chem. 2007;282:35772-86 pubmed
Kupershmidt L, Amit T, Bar Am O, Youdim M, Blumenfeld Z. The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases. J Neurochem. 2007;103:962-71 pubmed
Maeshima A, Vaughn D, Choi Y, Nigam S. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006;295:473-85 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

659-AB/CF

SKU :

659-AB-005/CF

product name :

Recombinant Human Activin B Protein, CF

Description :

The Recombinant Human Activin B Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Activin B Protein, CF has been validated for the following applications: Bioactivity.

target :

Activin B

category :

Proteins and Enzymes

unit size :

5 ug (also 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with Trehalose.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

12.4 kDa, reducing conditions

theoretical molecular weight :

12.8 kDa (monomer)

gene symbol :

INHBB

details of functionality :

Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al . (1991) Method Enzymol. 198 :340. The ED50 for this effect is 0.3-1.5 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q53T31

applications :

Bioactivity

source :

CHO-derived Recombinant Human Activin B Protein

USD :

318 USD

alt names :

activin AB beta polypeptide, Activin beta-B chain, INHBB, inhibin beta B chain, inhibin, beta B, inhibin, beta B (activin AB beta polypeptide), Inhibin, beta-2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.