product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Pleiotrophin/PTN Protein, CF
catalog :
6580-PL-050
quantity :
50 ug
price :
340 USD
more info or order :
R&D Systems product webpage
citations: 3
Reference
Himburg H, Roos M, Fang T, Zhang Y, Termini C, Schlussel L, et al. Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling. J Clin Invest. 2020;130:315-328 pubmed publisher
Nikolakopoulou A, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen M, et al. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019;22:1089-1098 pubmed publisher
Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G. The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-? signaling. Dev Biol. 2013;377:415-27 pubmed publisher
product information
brand :
R&D Systems
master code :
6580-PL
SKU :
6580-PL-050
product name :
Recombinant Mouse Pleiotrophin/PTN Protein, CF
description :
The Recombinant Mouse Pleiotrophin/PTN Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Mouse Pleiotrophin/PTN Protein, CF has been validated for the following applications: Bioactivity.
target :
Pleiotrophin/PTN
category :
Proteins and Enzymes
unit sizes :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
19 kDa, reducing conditions
theoretical molecular weight :
15.3 kDa
details of functionality :
Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cerebral cortical neurons. Muramatsu, H. and T. Muramatsu (1991) Biochem. Biophys. Res. Commu. 177 :652. Optimal neurite outgrowth was observed when neurons were plated on 96 well culture plates that had been pre-coated with 100 µL/well of recombinant mouse Pleiotrophin at 3-8 µg/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P63089
applications :
Bioactivity
source :
Sf 21 (baculovirus)-derived Recombinant Mouse Pleiotrophin/PTN Protein, CF
USD :
340 USD
alt names :
HARP, HBBM, HB-GAM, HBGF8, HBNF, HBNF1, HBNF-1, Heparin-binding brain mitogen, HNGF-8, NEGF1HBGF-8, neurite growth-promoting factor 1, neurite growth-promoting factor1), OSF-1, Osteoblast-specific factor 1, pleiotrophin, PTN
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.