Recombinant Human FGFR1 alpha (IIIc) Fc Chimera Protein, CF | R&D Systems 658-FR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human FGFR1 alpha (IIIc) Fc Chimera Protein, CF

catalog :

658-FR-050

quantity :

50 ug

price :

407 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Yanucil C, Kentrup D, Li X, Grabner A, Schramm K, Martinez E, et al. FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes. Sci Rep. 2022;12:7326 pubmed publisher
Chan W, Howe K, Clegg J, Guimond S, Price D, Turnbull J, et al. 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PLoS ONE. 2015;10:e0130147 pubmed publisher
Lu B, PereiraPerrin M. A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect Immun. 2008;76:3530-8 pubmed publisher
Martinez Torrecuadrada J, Cifuentes G, López Serra P, Saenz P, Martinez A, Casal J. Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation. Clin Cancer Res. 2005;11:6280-90 pubmed
Kessaris N, Jamen F, Rubin L, Richardson W. Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development. 2004;131:1289-98 pubmed

product information

master code :

658-FR

SKU :

658-FR-050

product name :

Recombinant Human FGFR1 alpha (IIIc) Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human FGFR1 alpha (IIIc) Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human FGFR1 alpha (IIIc) Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

FGFR1 alpha

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

100-110 kDa, reducing conditions

theoretical molecular weight :

66 kDa (monomer)

details of functionality :

Measured by its ability to inhibit FGF acidic-dependent proliferation of NR6R-3T3 mouse fibroblast cells. The ED50 for this effect is 1-3áng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_056934

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human FGFR1 alpha protein Human FGF R1 alpha (IIIc) (Arg22-Glu374) Accession # NP_056934 IEGRDMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

407 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage