Recombinant Human Endoglin/CD105 Fc Chimera Protein, CF | R&D Systems 6578-EN-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Endoglin/CD105 Fc Chimera Protein, CF

catalog :

6578-EN-025

quantity :

25 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Olsen O, Skjærvik A, Størdal B, Sundan A, Holien T. TGF-? contamination of purified recombinant GDF15. PLoS ONE. 2017;12:e0187349 pubmed publisher
Kapur N, Wilson S, Yunis A, Qiao X, Mackey E, Paruchuri V, et al. Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation. 2012;125:2728-38 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher

product information

master code :

6578-EN

SKU :

6578-EN-025

product name :

Recombinant Human Endoglin/CD105 Fc Chimera Protein, CF

unit size :

25 ug

description :

The Recombinant Human Endoglin/CD105 Fc Chimera Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Endoglin/CD105 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Endoglin/CD105

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

100-115 kDa, reducing conditions

theoretical molecular weight :

87.3 kDa (monomer)

gene symbol :

ENG

details of functionality :

Measured by its ability to inhibit BMP-10-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.3-1.2 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P17813

applications :

Bioactivity

source long :

Chinese Hamster Ovary cell line, CHO-derived human Endoglin/CD105 protein Human Endoglin (Met1-Gly586) Accession # P17813 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

CHO

USD :

432 USD

alt names :

CD105, CD105 antigen, endoglin, ENDOsler-Rendu-Weber syndrome 1, ENG, HHT1FLJ41744, ORW, ORW1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage