Recombinant Human ALCAM Fc Chimera Protein, CF | R&D Systems 656-AL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ALCAM Fc Chimera Protein, CF

catalog :

656-AL

quantity :

100 ug

price :

379 USD

citations: 6

Reference
Bughani U, Saha A, Kuriakose A, Nair R, Sadashivarao R, Venkataraman R, et al. T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab. PLoS ONE. 2017;12:e0180088 pubmed publisher
Carbotti G, Orengo A, Mezzanzanica D, Bagnoli M, Brizzolara A, Emionite L, et al. Activated leukocyte cell adhesion molecule soluble form: a potential biomarker of epithelial ovarian cancer is increased in type II tumors. Int J Cancer. 2013;132:2597-605 pubmed publisher
Ihnen M, Kress K, Kersten J, Kilic E, Choschzick M, Zander H, et al. Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients. BMC Cancer. 2012;12:140 pubmed publisher
Kulasingam V, Zheng Y, Soosaipillai A, Leon A, Gion M, Diamandis E. Activated leukocyte cell adhesion molecule: a novel biomarker for breast cancer. Int J Cancer. 2009;125:9-14 pubmed publisher
Ibáñez A, Sarrias M, Farnós M, Gimferrer I, Serra Pagès C, Vives J, et al. Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor. J Immunol. 2006;177:1152-9 pubmed
Zimmerman A, Joosten B, Torensma R, Parnes J, van Leeuwen F, Figdor C. Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. Blood. 2006;107:3212-20 pubmed

product information

brand :

R&D Systems

master code :

656-AL

SKU :

656-AL-100

product name :

Recombinant Human ALCAM Fc Chimera Protein, CF

description :

The Recombinant Human ALCAM Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ALCAM Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

ALCAM/CD166

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

120 kDa, reducing conditions

theoretical molecular weight :

83.5 kDa (monomer)

gene symbol :

ALCAM

details of functionality :

Measured by its ability to block adhesion of HuT 78 human cutaneous T cell lymphoma cells to immobilized Recombinant Human CD6 Fc Chimera (Catalog # 627-CD ). The ED50 for this effect is 0.3-1.5 µg/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

656-AL

accessionNumbers :

AAB59499

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human ALCAM/CD166 protein Human ALCAM (Trp28-Ala526) Accession # AAB59499 DIEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

extended description :

A New and Improved rh ALCAM is Available! ~2 fold better activity; HEK293 expressed; no His tag!

2020 USD :

379

2021 USD :

379 USD

product details :

A New and Improved rh ALCAM is Available! ~2 fold better activity; HEK293 expressed; no His tag!

alt names :

activated leucocyte cell adhesion molecule, activated leukocyte cell adhesion moleculeFLJ38514, CD166, CD166 antigen, MEMDMGC71733

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.