Recombinant Human ALCAM Fc Chimera Protein, CF | R&D Systems 656-AL-100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ALCAM Fc Chimera Protein, CF

catalog :

656-AL-100

quantity :

100 ug

price :

480 USD

citations: 8

Reference
Yang Y, Ye L, Ruge F, Fang Z, Ji K, Sanders A, et al. Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential 'Seed' and 'Soil' Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers. Int J Mol Sci. 2023;24: pubmed publisher
Cegarra C, Cameron B, Chaves C, Dabdoubi T, Do T, Gen xea t B, et al. An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family. PLoS ONE. 2022;17:e0274667 pubmed publisher
Bughani U, Saha A, Kuriakose A, Nair R, Sadashivarao R, Venkataraman R, et al. T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab. PLoS ONE. 2017;12:e0180088 pubmed publisher
Carbotti G, Orengo A, Mezzanzanica D, Bagnoli M, Brizzolara A, Emionite L, et al. Activated leukocyte cell adhesion molecule soluble form: a potential biomarker of epithelial ovarian cancer is increased in type II tumors. Int J Cancer. 2013;132:2597-605 pubmed publisher
Ihnen M, Kress K, Kersten J, Kilic E, Choschzick M, Zander H, et al. Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients. BMC Cancer. 2012;12:140 pubmed publisher
Kulasingam V, Zheng Y, Soosaipillai A, Leon A, Gion M, Diamandis E. Activated leukocyte cell adhesion molecule: a novel biomarker for breast cancer. Int J Cancer. 2009;125:9-14 pubmed publisher
Ibáñez A, Sarrias M, Farnós M, Gimferrer I, Serra Pagès C, Vives J, et al. Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor. J Immunol. 2006;177:1152-9 pubmed
Zimmerman A, Joosten B, Torensma R, Parnes J, van Leeuwen F, Figdor C. Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. Blood. 2006;107:3212-20 pubmed

product information

master code :

656-AL

SKU :

656-AL-100

product name :

Recombinant Human ALCAM Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Human ALCAM Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ALCAM Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

ALCAM/CD166

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

99-115 kDa, reducing conditions

theoretical molecular weight :

83.5 kDa (monomer)

gene symbol :

ALCAM

details of functionality :

Measured by its ability to block adhesion of HuT 78 human cutaneous T cell lymphoma cells to immobilized Recombinant Human CD6 Fc Chimera (Catalog # 627-CD ). The ED50 for this effect is 0.3-1.5 ╡g/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAB59499

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human ALCAM/CD166 protein Human ALCAM (Trp28-Ala526) Accession # AAB59499 DIEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

source short :

NS0

USD :

480 USD

alt names :

activated leucocyte cell adhesion molecule, activated leukocyte cell adhesion moleculeFLJ38514, CD166, CD166 antigen, MEMDMGC71733

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.