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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Neurocan Protein, CF
catalog :
6508-NC-050
quantity :
50 ug
price :
524 USD
more info or order :
R&D Systems product webpage
citations: 3
Reference
Bielsa N, Casasampere M, Aseeri M, Casas J, Delgado A, Abad J, et al. Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells. Eur J Med Chem. 2021;216:113296 pubmed publisher
Sullivan C, Gotthard I, Wyatt E, Bongu S, Mohan V, Weinberg R, et al. Perineuronal Net Protein Neurocan Inhibits NCAM/EphA3 Repellent Signaling in GABAergic Interneurons. Sci Rep. 2018;8:6143 pubmed publisher
Su Z, Kishida S, Tsubota S, Sakamoto K, Cao D, Kiyonari S, et al. Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. Oncotarget. 2017;8:106296-106310 pubmed publisher
product information
brand :
R&D Systems
master code :
6508-NC
SKU :
6508-NC-050
product name :
Recombinant Human Neurocan Protein, CF
unit size :
50 ug
seo description :
The Recombinant Human Neurocan Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Neurocan Protein, CF has been validated for the following applications: Bioactivity.
target :
Neurocan
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
140-290 kDa, reducing conditions
theoretical molecular weight :
141.5 kDa
gene symbol :
NCAN
details of functionality :
Measured by the ability of the immobilized protein to enhance the adhesion of H4 human neuroglioma cells. When 5 x 104 cells per well are added to recombinant human Neurocan coated plates, cell adhesion is enhanced in a dose dependent manner. The ED50 for this effect is 50-200 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
O14594
applications :
Bioactivity
source :
CHO-derived Recombinant Human Neurocan Protein, CF
USD :
524 USD
alt names :
Chondroitin sulfate proteoglycan 3, chondroitin sulfate proteoglycan 3 (neurocan), CSPG3, CSPG3neurocan core protein, FLJ44681, NCAN, NEUR, neurocan, neurocan proteoglycan
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.