product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TRANCE/RANK L/TNFSF11 (E. coli), CF
catalog :
6449-TEC-010/CF
quantity :
10 ug (also 50 ug, 200 ug, 1 mg)
price :
400 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Liu R, Zhong Y, Chen R, Chen S, Huang Y, Liu H. Bacterial infections exacerbate myeloma bone disease. J Transl Med. 2022;20:16 pubmed publisher
Smith B, Kaufman M, Wise S, Ahn Y, Caldwell T, Leary C, et al. Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages. Mol Cancer Ther. 2021;20:2098-2109 pubmed publisher
Chen H, Shen G, Shang Q, Zhang P, Yu D, Yu X, et al. Plastrum testudinis extract suppresses osteoclast differentiation via the NF-κB signaling pathway and ameliorates senile osteoporosis. J Ethnopharmacol. 2021;276:114195 pubmed publisher
Shang W, Zhao L, Dong X, Zhao Z, Li J, Zhang B, et al. Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways. Mol Med Rep. 2016;14:3620-6 pubmed publisher
product information
brand :
R&D Systems
catalog number base :
6449-TEC/CF
SKU :
6449-TEC-010/CF
product name :
Recombinant Human TRANCE/RANK L/TNFSF11 (E. coli), CF
units size :
10 ug (also 50 ug, 200 ug, 1 mg)
description :
The Recombinant Human TRANCE/RANK L/TNFSF11 (E. coli), CF from R&D Systems is derived from E. coli. The Recombinant Human TRANCE/RANK L/TNFSF11 (E. coli), CF has been validated for the following applications: Bioactivity.
target :
TRANCE/TNFSF11/RANK L
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in MES and NaCl.
conjugate :
Unconjugated
all_available conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
19 kDa, reducing conditions
theoretical molecular weight :
18.3 kDa
gene symbol :
TNFSF11
details of functionality :
Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED50 for this effect is 2-12 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
top caption :
Graph showing dose-dependent bioactivity of Human TRANCE protein
accessionNumbers :
AAC51762
applications :
Bioactivity
source :
E. coli-derived Recombinant Human TRANCE/RANK L/TNFSF11 (E. coli), CF
USD :
400 USD
alt names :
CD254, CD254 antigen, ODF, OPGL, OPGLOPTB2, Osteoclast differentiation factor, Osteoprotegerin ligand, RANK L, RANKL, RANKLreceptor activator of nuclear factor kappa B ligand, Receptor activator of nuclear factor kappa-B ligand, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCEODFhRANKL2, tumor necrosis factor (ligand) superfamily, member 11, tumor necrosis factor ligand superfamily member 11
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.