Recombinant Human EphA3 Fc Chimera Protein, CF | R&D Systems 6444-A3-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human EphA3 Fc Chimera Protein, CF

catalog :

6444-A3-050

quantity :

50 ug

price :

443 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Nishida M, Sato A, Shimizu A, Rahman N, Wada A, Kageyama S, et al. EphA-Mediated Regulation of Stomatin Expression in Prostate Cancer Cells. Cancer Med. 2024;13:e70276 pubmed publisher
El Fakiri M, Regupathy A, Uhlmann L, Ayada N, Geis N, Domogalla L, et al. Development and preclinical characterization of a novel radiotheranostic EphA2-targeting bicyclic peptide. Theranostics. 2024;14:4701-4712 pubmed publisher
Cha J, Chan L, Wang Y, Chu Y, Wang C, Lee H, et al. Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. J Biol Chem. 2022;298:101817 pubmed publisher
Itoh T, Hatano R, Horimoto Y, Yamada T, Song D, Otsuka H, et al. IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells. Cell Death Dis. 2021;12:520 pubmed publisher
Martinez Martin N, Ramani S, Hackney J, Tom I, Wranik B, Chan M, et al. The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation. Nat Commun. 2016;7:11473 pubmed publisher

product information

master code :

6444-A3

SKU :

6444-A3-050

product name :

Recombinant Human EphA3 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human EphA3 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human EphA3 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

EphA3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

100-110 kDa, reducing conditions

theoretical molecular weight :

85.4 kDa (monomer)

gene symbol :

EPHA3

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human (rh) EphA3 Fc Chimera is coated at 2 ╡g/mL (100 ╡L/well), the concentration of biotinylayed rhEphrin A5 Fc Chimera that produces 50% of the optimal binding response is found to be approximately 5 - 25 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_005224

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human EphA3 protein Human EphA3 (Met1 - Gln541) Accession # NP_005224 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

NS0

USD :

443 USD

alt names :

Cek4, EC 2.7.10, EC 2.7.10.1, EK4, EPH receptor A3, EphA3, EPH-like kinase 4, ephrin type-A receptor 3, ETK, hEK4, HEKETK1eph-like tyrosine kinase 1, human embryo kinase 1, Tyro4, TYRO4 protein tyrosine kinase, Tyrosine-protein kinase receptor ETK1, Tyrosine-protein kinase TYRO4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage