product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse EphA4 Fc Chimera Protein, CF
catalog :
641-A4-200
quantity :
200 ug
price :
341 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Defourny J, Audouard C, Davy A, Thiry M. Efnb2 haploinsufficiency induces early gap junction plaque disassembly and endocytosis in the cochlea. Brain Res Bull. 2021;174:153-160 pubmed publisher
Gu S, Fu W, Fu A, Tong E, Ip F, Huang X, et al. Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs. Sci Rep. 2018;8:7377 pubmed publisher
Schoonaert L, Rue L, Roucourt B, Timmers M, Little S, Chávez Gutiérrez L, et al. Identification and characterization of Nanobodies targeting the EphA4 receptor. J Biol Chem. 2017;292:11452-11465 pubmed publisher
Weiss A, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe M, et al. Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme. Development. 2014;141:3420-30 pubmed publisher
Stojanovic A, Fiegler N, Brunner Weinzierl M, Cerwenka A. CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-? production in response to mature dendritic cells. J Immunol. 2014;192:4184-91 pubmed publisher
Han X, Xu Y, Yang Y, Xi J, Tian W, Duggineni S, et al. Discovery and characterization of a novel cyclic peptide that effectively inhibits ephrin binding to the EphA4 receptor and displays anti-angiogenesis activity. PLoS ONE. 2013;8:e80183 pubmed publisher
Stiffel V, Amoui M, Sheng M, Mohan S, Lau K. EphA4 receptor is a novel negative regulator of osteoclast activity. J Bone Miner Res. 2014;29:804-19 pubmed publisher
Afshari F, Kwok J, Fawcett J. Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J Neurosci. 2010;30:4246-55 pubmed publisher
Petros T, Williams S, Mason C. Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development. Mol Cell Neurosci. 2006;32:49-66 pubmed
Murai K, Nguyen L, Koolpe M, McLennan R, Krull C, Pasquale E. Targeting the EphA4 receptor in the nervous system with biologically active peptides. Mol Cell Neurosci. 2003;24:1000-11 pubmed
Murai K, Nguyen L, Irie F, Yamaguchi Y, Pasquale E. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci. 2003;6:153-60 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
641-A4
SKU :
641-A4-200
product name :
Recombinant Mouse EphA4 Fc Chimera Protein, CF
Description :
The Recombinant Mouse EphA4 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse EphA4 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
EphA4
category :
Proteins and Enzymes
unit size :
200 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in MES, NaCl, CHAPS, Imidazole and PEG 3350.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
110 kDa, reducing conditions
theoretical molecular weight :
85.7 kDa (monomer)
gene symbol :
Epha4
details of functionality :
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse EphA4 Fc Chimera at 2 µg/mL (100 µL/well) can bind recombinant human Ephrin-A5 Fc Chimera with a linear range of 0.16-10 ng/mL. Optimal dilutions should be determined by each laboratory for each application.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q03137
applications :
Binding Activity
source :
NS0-derived Recombinant Mouse EphA4 Fc Chimera Protein
USD :
341 USD
alt names :
Cek8, EC 2.7.10, EC 2.7.10.1, EK8, EPH receptor A4, EphA4, EPH-like kinase 8, ephrin type-A receptor 4, HEK8, receptor protein-tyrosine kinase HEK8, SEK, Sek1, Tyro1, TYRO1 protein tyrosine kinase, Tyrosine-protein kinase receptor SEK, Tyrosine-protein kinase TYRO1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.