Recombinant Mouse EphA4 Fc Chimera Protein, CF | R&D Systems 641-A4-200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse EphA4 Fc Chimera Protein, CF

catalog :

641-A4-200

quantity :

200 ug

price :

348 USD

citations: 15

Reference
Eid L, Lokmane L, Raju P, Tene Tadoum S, Jiang X, Toulouse K, et al. Both GEF domains of the autism and developmental epileptic encephalopathy-associated Trio protein are required for proper tangential migration of GABAergic interneurons. Mol Psychiatry. 2024;: pubmed publisher
Vecchi J, Rhomberg M, Allan Guymon C, Hansen M. Inositol trisphosphate and ryanodine receptor signaling distinctly regulate neurite pathfinding in response to engineered micropatterned surfaces. PLoS ONE. 2024;19:e0308389 pubmed publisher
Asadi F, Gunawardana S, Dolle R, Piston D. An orally available compound suppresses glucagon hypersecretion and normalizes hyperglycemia in type 1 diabetes. JCI Insight. 2024;9: pubmed publisher
Defourny J, Audouard C, Davy A, Thiry M. Efnb2 haploinsufficiency induces early gap junction plaque disassembly and endocytosis in the cochlea. Brain Res Bull. 2021;174:153-160 pubmed publisher
Gu S, Fu W, Fu A, Tong E, Ip F, Huang X, et al. Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs. Sci Rep. 2018;8:7377 pubmed publisher
Schoonaert L, Rue L, Roucourt B, Timmers M, Little S, Chávez Gutiérrez L, et al. Identification and characterization of Nanobodies targeting the EphA4 receptor. J Biol Chem. 2017;292:11452-11465 pubmed publisher
Weiss A, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe M, et al. Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme. Development. 2014;141:3420-30 pubmed publisher
Stojanovic A, Fiegler N, Brunner Weinzierl M, Cerwenka A. CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-? production in response to mature dendritic cells. J Immunol. 2014;192:4184-91 pubmed publisher
Han X, Xu Y, Yang Y, Xi J, Tian W, Duggineni S, et al. Discovery and characterization of a novel cyclic peptide that effectively inhibits ephrin binding to the EphA4 receptor and displays anti-angiogenesis activity. PLoS ONE. 2013;8:e80183 pubmed publisher
Stiffel V, Amoui M, Sheng M, Mohan S, Lau K. EphA4 receptor is a novel negative regulator of osteoclast activity. J Bone Miner Res. 2014;29:804-19 pubmed publisher
Tai A, Cassidy R, Kromer L. EphA7 expression identifies a unique neuronal compartment in the rat striatum. J Comp Neurol. 2013;521:2663-79 pubmed publisher
Afshari F, Kwok J, Fawcett J. Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J Neurosci. 2010;30:4246-55 pubmed publisher
Petros T, Williams S, Mason C. Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development. Mol Cell Neurosci. 2006;32:49-66 pubmed
Murai K, Nguyen L, Koolpe M, McLennan R, Krull C, Pasquale E. Targeting the EphA4 receptor in the nervous system with biologically active peptides. Mol Cell Neurosci. 2003;24:1000-11 pubmed
Murai K, Nguyen L, Irie F, Yamaguchi Y, Pasquale E. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci. 2003;6:153-60 pubmed

product information

master code :

641-A4

SKU :

641-A4-200

product name :

Recombinant Mouse EphA4 Fc Chimera Protein, CF

unit size :

200 ug

description :

The Recombinant Mouse EphA4 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse EphA4 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

EphA4

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in MES, NaCl, CHAPS, Imidazole and PEG 3350.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

110 kDa, reducing conditions

theoretical molecular weight :

85.7 kDa (monomer)

gene symbol :

Epha4

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse EphA4 Fc Chimera at 2 ╡g/mL (100 ╡L/well) can bind recombinant human Ephrin-A5 Fc Chimera with a linear range of 0.16-10 ng/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q03137

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived mouse EphA4 protein Mouse EphA4 (Val20-Thr547) Accession # Q03137 IEGRMD Human IgG1 (Pro100-Lys330) 6 His tag N-terminus C-terminus

source short :

NS0

USD :

348 USD

alt names :

Cek8, EC 2.7.10, EC 2.7.10.1, EK8, EPH receptor A4, EphA4, EPH-like kinase 8, ephrin type-A receptor 4, HEK8, receptor protein-tyrosine kinase HEK8, SEK, Sek1, Tyro1, TYRO1 protein tyrosine kinase, Tyrosine-protein kinase receptor SEK, Tyrosine-protein kinase TYRO1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.