Recombinant Mouse EphA2 Fc Chimera Protein, CF | R&D Systems 639-A2-200 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse EphA2 Fc Chimera Protein, CF

catalog :

639-A2-200

quantity :

200 ug

price :

341 USD

more info or order :

R&D Systems product webpage

citations: 10

Reference
Kohara S, Ogawa K. Eph/Ephrin Promotes the Adhesion of Liver Tissue-Resident Macrophages to a Mimicked Surface of Liver Sinusoidal Endothelial Cells. Biomedicines. 2022;10: pubmed publisher
Darling T, Mimche P, Bray C, Umaru B, Brady L, Stone C, et al. EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS Pathog. 2020;16:e1008261 pubmed publisher
Takasugi M, Okada R, Takahashi A, Virya Chen D, Watanabe S, Hara E. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2. Nat Commun. 2017;8:15729 pubmed publisher
Ullman C, Mathonet P, Oleksy A, Diamandakis A, Tomei L, Demartis A, et al. High Affinity Binders to EphA2 Isolated from Abdurin Scaffold Libraries; Characterization, Binding and Tumor Targeting. PLoS ONE. 2015;10:e0135278 pubmed publisher
Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, et al. ADAM12-cleaved ephrin-A1 contributes to lung metastasis. Oncogene. 2014;33:2179-90 pubmed publisher
Giorgio C, Hassan Mohamed I, Flammini L, Barocelli E, Incerti M, Lodola A, et al. Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation. PLoS ONE. 2011;6:e18128 pubmed publisher
Afshari F, Kwok J, Fawcett J. Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J Neurosci. 2010;30:4246-55 pubmed publisher
Cercone M, Schroeder W, Schomberg S, Carpenter T. EphA2 receptor mediates increased vascular permeability in lung injury due to viral infection and hypoxia. Am J Physiol Lung Cell Mol Physiol. 2009;297:L856-63 pubmed publisher
Jackson D, Gooya J, Mao S, Kinneer K, Xu L, Camara M, et al. A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo. Cancer Res. 2008;68:9367-74 pubmed publisher
Dobrzanski P, Hunter K, Jones Bolin S, Chang H, Robinson C, Pritchard S, et al. Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist. Cancer Res. 2004;64:910-9 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

639-A2

SKU :

639-A2-200

product name :

Recombinant Mouse EphA2 Fc Chimera Protein, CF

Description :

The Recombinant Mouse EphA2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse EphA2 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

EphA2

category :

Proteins and Enzymes

unit size :

200 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris-HCl and EDTA.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

observed molecular weight :

105 kDa, reducing conditions

theoretical molecular weight :

84 kDa (monomer)

gene symbol :

Epha2

details of functionality :

Measured by its ability to bind Recombinant Mouse Ephrin-A1 Fc Chimera (Catalog # 602-A1 ) in a functional ELISA. Immobilized Recombinant Mouse EphA2 Fc Chimera at 2 µg/mL (100 µL/well) can bind Recombinant Mouse Ephrin-A1 Fc Chimera with a linear range of 0.078-5 ng/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

AAA82113

applications :

Binding Activity

source :

NS0-derived Recombinant Mouse EphA2 Fc Chimera Protein

USD :

341 USD

alt names :

ARCC2, EC 2.7.10, EC 2.7.10.1, Eck, ECKepithelial cell receptor protein tyrosine kinase, EPH receptor A2, EphA2, ephrin type-A receptor 2, Epithelial cell kinase, Myk2, Sek2, soluble EPHA2 variant 1, Tyrosine-protein kinase receptor ECK

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage