Recombinant Human Activin RIA/ALK-2 Fc Chimera Protein, CF | R&D Systems 637-AR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Activin RIA/ALK-2 Fc Chimera Protein, CF

catalog :

637-AR-100

quantity :

100 ug

price :

468 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Srole D, Jung G, Waring A, Nemeth E, Ganz T. Characterization of erythroferrone structural domains relevant to its iron-regulatory function. J Biol Chem. 2023;299:105374 pubmed publisher
Huang B, Yuan Y, Li T, Ding S, Zhang W, Gu Y, et al. Facilitated receptor-recognition and enhanced bioactivity of bone morphogenetic protein-2 on magnesium-substituted hydroxyapatite surface. Sci Rep. 2016;6:24323 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
Reversade B, De Robertis E. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 2005;123:1147-60 pubmed

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

637-AR

SKU :

637-AR-100

product name :

Recombinant Human Activin RIA/ALK-2 Fc Chimera Protein, CF

description :

The Recombinant Human Activin RIA/ALK-2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Activin RIA/ALK-2 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Activin RIA/ALK-2

unit size :

100 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

40-45 kDa 34-38 kDa, reducing conditions

theoretical molecular weight :

39 kDa 28 kDa (monomers)

gene symbol :

ACVR1

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human BMP-6 (Catalog # 507-BP ) is used at 0.25 µg/mL, the concentration of Recombinant Human Activin RIA/ALK-2 Fc Chimera that produces 50% of the optimal binding response is found to be approximately 1-5 µg/mL.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q53SV1

applications :

Binding Activity

product keywords :

637-AR, rhActivin RIA/ALK-2/Fc, hActivin RIA, carrier-free, carrier free, 637AR, ActivinRIA, ALK2, ActivinRIA, Activin Receptor IA, ActRIA, cytokine, cytokines

source :

NS0-derived Recombinant Human Activin RIA/ALK-2 Fc Chimera Protein, CF

USD :

458

USD 2025 :

468 USD

alt names :

activin A receptor, type I, ActivinRIA, ACTRI, ACVR1, ACVR1A, ACVRLK2, ALK2, ALK-2, FOP, SKR1, TSRI

more info or order :

R&D Systems product webpage