Recombinant Human sTNF RI/TNFRSF1A Protein, CF | R&D Systems 636-R1-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human sTNF RI/TNFRSF1A Protein, CF

catalog :

636-R1-025/CF

quantity :

25 ug

price :

417 USD

more info or order :

R&D Systems product webpage

citations: 14

Reference
Baram T, Oren N, Erlichman N, Meshel T, Ben Baruch A. Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher
Huie J, Ferguson A, Kyritsis N, Pan J, Irvine K, Nielson J, et al. Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury. Sci Rep. 2021;11:3442 pubmed publisher
Clausen B, Wirenfeldt M, Høgedal S, Frich L, Nielsen H, Schrøder H, et al. Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke. Acta Neuropathol Commun. 2020;8:81 pubmed publisher
Konge J, Leteurtre F, Goislard M, Biard D, Morel Altmeyer S, Vaurijoux A, et al. Breast cancer stem cell-like cells generated during TGFβ-induced EMT are radioresistant. Oncotarget. 2018;9:23519-23531 pubmed publisher
Goodall L, Ovecka M, Rycroft D, Friel S, Sanderson A, Mistry P, et al. Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension. PLoS ONE. 2015;10:e0137065 pubmed publisher
Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, et al. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci. 2015;56:1051-62 pubmed publisher
Wong J, Muthuswamy R, Bartlett D, Kalinski P. IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients. Oncoimmunology. 2013;2:e26245 pubmed
Colucci S, Brunetti G, Mori G, Oranger A, Centonze M, Mori C, et al. Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients. Leukemia. 2009;23:2139-46 pubmed publisher
Ferguson A, Christensen R, Gensel J, Miller B, Sun F, Beattie E, et al. Cell death after spinal cord injury is exacerbated by rapid TNF alpha-induced trafficking of GluR2-lacking AMPARs to the plasma membrane. J Neurosci. 2008;28:11391-400 pubmed publisher
Dulos J, van der Vleuten M, Kavelaars A, Heijnen C, Boots A. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum. 2005;52:770-8 pubmed
Mozaffarian D, Rimm E, King I, Lawler R, McDonald G, Levy W. trans fatty acids and systemic inflammation in heart failure. Am J Clin Nutr. 2004;80:1521-5 pubmed
Copeland S, Siddiqui J, Remick D. Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J Immunol Methods. 2004;284:99-106 pubmed
Jyonouchi H, Sun S, Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology. 2002;46:76-84 pubmed
Bharucha A, Jorgensen R, Lichtman S, LaRusso N, Lindor K. A pilot study of pentoxifylline for the treatment of primary sclerosing cholangitis. Am J Gastroenterol. 2000;95:2338-42 pubmed

product information

brand :

R&D Systems

master code :

636-R1/CF

SKU :

636-R1-025/CF

product name :

Recombinant Human sTNF RI/TNFRSF1A Protein, CF

description :

The Recombinant Human sTNF RI/TNFRSF1A Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human sTNF RI/TNFRSF1A Protein, CF has been validated for the following applications: Bioactivity.

target :

TNF RI/TNFRSF1A

category :

Proteins and Enzymes

unit sizes :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

21 kDa

gene symbol :

TNFRSF1A

details of functionality :

Measured by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 221. The ED50 for this effect, in the presence of 0.25 ng/mL of recombinant human TNF-alpha , is 0.045-0.09 µg/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P19438.1

applications :

Bioactivity

source :

E. coli-derived Recombinant Human sTNF RI/TNFRSF1A Protein, CF

USD :

417 USD

alt names :

CD120a, CD120a antigen, FPF, p55, p55-R, p60, TNFARMGC19588, TNF-R, TNF-R1, TNFR1TBP1, TNFR55, TNF-R55, TNFR60, TNFRI, TNF-RI, TNF-R-I, TNFR-I, TNFRSF1A, tumor necrosis factor binding protein 1, Tumor necrosis factor receptor 1, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, tumor necrosis factor-alpha receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage