Recombinant Mouse TIMP-2 Protein, CF | R&D Systems 6304-TM-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse TIMP-2 Protein, CF

catalog :

6304-TM-010

quantity :

10 ug

price :

493 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Wang X, Rojas Quintero J, Wilder J, Tesfaigzi Y, Zhang D, Owen C. Tissue Inhibitor of Metalloproteinase-1 Promotes Polymorphonuclear Neutrophil (PMN) Pericellular Proteolysis by Anchoring Matrix Metalloproteinase-8 and -9 to PMN Surfaces. J Immunol. 2019;202:3267-3281 pubmed publisher
Castellano J, Mosher K, Abbey R, McBride A, James M, Berdnik D, et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature. 2017;544:488-492 pubmed publisher
Ohrvik H, Logeman B, Turk B, Reinheckel T, Thiele D. Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain. J Biol Chem. 2016;291:13905-16 pubmed publisher
Sanz R, Ferraro G, Fournier A. IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth. J Biol Chem. 2015;290:4330-42 pubmed publisher
Birukawa N, Murase K, Sato Y, Kosaka A, Yoneda A, Nishita H, et al. Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth. J Biol Chem. 2014;289:20209-21 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

6304-TM

SKU :

6304-TM-010

product name :

Recombinant Mouse TIMP-2 Protein, CF

Description :

The Recombinant Mouse TIMP-2 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse TIMP-2 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

TIMP-2

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane

species :

Mouse

observed molecular weight :

22 kDa, reducing conditions

theoretical molecular weight :

22 kDa

gene symbol :

Timp2

details of functionality :

Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The IC50 value is 2 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_035724

applications :

Enzyme Activity

source :

NS0-derived Recombinant Mouse TIMP-2 Protein

USD :

493 USD

alt names :

CSC-21Ktissue inhibitor of metalloproteinase 2, metalloproteinase inhibitor 2, TIMP metallopeptidase inhibitor 2, TIMP2, TIMP-2, Tissue inhibitor of metalloproteinases 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage