Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera Protein | R&D Systems 630-TR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera Protein

catalog :

630-TR

quantity :

100 ug

price :

359 USD

citations: 2

Reference
Lee Y, Hwang E, Jang Y. Involvement of p38 Activation and Mitochondria in Death of Human Leukemia Cells Induced by an Agonistic Human Monoclonal Antibody Fab Specific to TRAIL Receptor 1. Int J Mol Sci. 2019;20: pubmed publisher
Gasparian M, Chernyak B, Dolgikh D, Yagolovich A, Popova E, Sycheva A, et al. Generation of new TRAIL mutants DR5-A and DR5-B with improved selectivity to death receptor 5. Apoptosis. 2009;14:778-87 pubmed publisher

product information

brand :

R&D Systems

master code :

630-TR

SKU :

630-TR-100

product name :

Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera Protein

description :

The Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera Protein has been validated for the following applications: Bioactivity.

target :

TRAILR3/TNFRSF10C

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

75-90 kDa, reducing conditions

theoretical molecular weight :

48 kDa (monomer)

gene symbol :

TNFRSF10C

details of functionality :

Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 15-60 ng/mL in the presence of 12 ng/mL of rhTRAIL (Catalog # 375-TEC).

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

630-TR

accessionNumbers :

Q05D71

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human TRAIL R3/TNFRSF10C protein TRAIL R3 (Ala26 - Ala221) Accession # Q05D71 IEGRMD Human IgG1 (Pro100 - Lys330) 6-His tag N-terminus C-terminus

2020 USD :

359

2021 USD :

359 USD

alt names :

Antagonist decoy receptor for TRAIL/Apo-2L, CD263, CD263 antigen, cytotoxic TRAIL receptor-3, DcR1, DCR1MGC149502, Decoy receptor 1, Decoy TRAIL receptor without death domain, LITMGC149501, Lymphocyte inhibitor of TRAIL, TNFRSF10C, TRAIL receptor 3, TRAIL receptor without an intracellular domain, TRAILR3, TRAIL-R3, TRAILR3TNF-related apoptosis-inducing ligand receptor 3, TRIDDCR1-TNFR, tumor necrosis factor receptor superfamily member 10C, tumor necrosis factor receptor superfamily, member 10c, decoy without anintracellular domain

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.