product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera Protein
catalog :
630-TR-100
quantity :
100 ug
price :
447 USD
more info or order :
R&D Systems product webpage
citations: 3
Reference
Tsai C, Sun D, Su M, Lien T, Chen Y, Lin C, et al. Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice. Sci Rep. 2020;10:6294 pubmed publisher
Lee Y, Hwang E, Jang Y. Involvement of p38 Activation and Mitochondria in Death of Human Leukemia Cells Induced by an Agonistic Human Monoclonal Antibody Fab Specific to TRAIL Receptor 1. Int J Mol Sci. 2019;20: pubmed publisher
Gasparian M, Chernyak B, Dolgikh D, Yagolovich A, Popova E, Sycheva A, et al. Generation of new TRAIL mutants DR5-A and DR5-B with improved selectivity to death receptor 5. Apoptosis. 2009;14:778-87 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
630-TR
SKU :
630-TR-100
product name :
Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera Protein
Description :
The Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera Protein has been validated for the following applications: Bioactivity.
target :
TRAIL R3/TNFRSF10C
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
75-90 kDa, reducing conditions
theoretical molecular weight :
48 kDa (monomer)
gene symbol :
TNFRSF10C
details of functionality :
Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 15-60 ng/mL in the presence of 12 ng/mL of rhTRAIL (Catalog # 375-TEC).
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q05D71
applications :
Bioactivity
source :
NS0-derived Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera Protein
USD :
447 USD
alt names :
Antagonist decoy receptor for TRAIL/Apo-2L, CD263, CD263 antigen, cytotoxic TRAIL receptor-3, DcR1, DCR1MGC149502, Decoy receptor 1, Decoy TRAIL receptor without death domain, LITMGC149501, Lymphocyte inhibitor of TRAIL, TNFRSF10C, TRAIL receptor 3, TRAIL receptor without an intracellular domain, TRAILR3, TRAIL-R3, TRAILR3TNF-related apoptosis-inducing ligand receptor 3, TRIDDCR1-TNFR, tumor necrosis factor receptor superfamily member 10C, tumor necrosis factor receptor superfamily, member 10c, decoy without anintracellular domain
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.