Recombinant C. difficile Toxin B/TcdB Protein, CF | R&D Systems 6246-GT-020 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant C. difficile Toxin B/TcdB Protein, CF

catalog :

6246-GT-020

quantity :

20 ug

price :

432 USD

citations: 6

Reference
Tubau Juni N, Bassaganya Riera J, Leber A, Alva S, Baker R, Hontecillas R. Modulation of colonic immunometabolic responses during Clostridioides difficile infection ameliorates disease severity and inflammation. Sci Rep. 2023;13:14708 pubmed publisher
Gangopadhyay A, Devi S, Tenguria S, Carrière J, Nguyen H, Jäger E, et al. NLRP3 licenses NLRP11 for inflammasome activation in human macrophages. Nat Immunol. 2022;23:892-903 pubmed publisher
Howell C, Mikhalovsky S, Markaryan E, Khovanov A. Investigation of the adsorption capacity of the enterosorbent Enterosgel for a range of bacterial toxins, bile acids and pharmaceutical drugs. Sci Rep. 2019;9:5629 pubmed publisher
Stroke I, Letourneau J, Miller T, Xu Y, Pechik I, Savoly D, et al. Treatment of Clostridium difficile Infection with a Small-Molecule Inhibitor of Toxin UDP-Glucose Hydrolysis Activity. Antimicrob Agents Chemother. 2018;62: pubmed publisher
Mao L, Kitani A, Similuk M, Oler A, Albenberg L, Kelsen J, et al. Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease. J Clin Invest. 2018;128:1793-1806 pubmed publisher
Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed publisher

product information

master code :

6246-GT

SKU :

6246-GT-020

product name :

Recombinant C. difficile Toxin B/TcdB Protein, CF

unit size :

20 ug

description :

The Recombinant C. difficile Toxin B/TcdB Protein, CF from R&D Systems is derived from E. coli. The Recombinant C. difficile Toxin B/TcdB Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Toxin B/TcdB

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

species :

C. difficile

observed molecular weight :

60-65 kDa, reducing conditions

theoretical molecular weight :

64 kDa

gene symbol :

tcdB

details of functionality :

Measured by its ability to hydrolyze UDP-Glucose. The specific activity is 45 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P18177

applications :

Enzyme Activity

source long :

E. coli -derived c. difficile Toxin B/TcdB protein Met1-Leu543, with a C-terminal 6-His tag

source short :

E. coli

USD :

432 USD

alt names :

toxB

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.