Recombinant Human CD40 Ligand/TNFSF5 (aa 108-261) Protein | R&D Systems 6245-CL-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CD40 Ligand/TNFSF5 (aa 108-261) Protein

catalog :

6245-CL-050

quantity :

50 ug (also 1 mg)

price :

408 USD

citations: 7

Reference
Eiza N, Kessler O, Sabag A, Neufeld G, Jones E, Vadasz Z. Truncated-semaphorin3A is a potential regulatory molecule to restore immune homeostasis in immune-mediated diseases. Front Pharmacol. 2022;13:1085892 pubmed publisher
Lee J, Fra Bido S, Burton A, Innocentin S, Hill D, Linterman M. B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction. Aging Cell. 2022;21:e13692 pubmed publisher
Kim J, Islam S, Qiao F, Singh A, Khan M, Won J, et al. Regulation of B cell functions by S-nitrosoglutathione in the EAE model. Redox Biol. 2021;45:102053 pubmed publisher
Artyomov M, Munk A, Gorvel L, Korenfeld D, Cella M, Tung T, et al. Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells. J Exp Med. 2015;212:743-57 pubmed publisher
Singh M, Davidson D, Jackson J, Singh V, Silva J, Ramirez S, et al. Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation. J Immunol. 2014;192:4674-84 pubmed publisher
Morandi F, Di Carlo E, Ferrone S, Petretto A, Pistoia V, Airoldi I. IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation. J Immunol. 2014;192:2634-42 pubmed publisher
Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, et al. IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol. 2012;10:e1001395 pubmed publisher

product information

master code :

6245-CL

SKU :

6245-CL-050

product name :

Recombinant Human CD40 Ligand/TNFSF5 (aa 108-261) Protein

unit size :

50 ug (also 1 mg)

description :

The Recombinant Human CD40 Ligand/TNFSF5 (aa 108-261) Protein from R&D Systems is derived from E. coli. The Recombinant Human CD40 Ligand/TNFSF5 (aa 108-261) Protein has been validated for the following applications: Bioactivity.

target :

CD40 Ligand/TNFSF5

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris-HCL, NaCl and EDTA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

18 kDa, reducing conditions

theoretical molecular weight :

16.9 kDa (monomer)

gene symbol :

CD40LG

details of functionality :

Measured by its binding ability in a functional ELISA. Recombinant Human CD40 Ligand/TNFSF5 aa 108-261 (Catalog # 6245-CL) binds to Recombinant Human CD40/TNFRSF5 Fc Chimera (Catalog # 1493-CDB ) with an ED50 of 0.300-3.60 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P29965

applications :

Bioactivity

source long :

E. coli -derived human CD40 Ligand/TNFSF5 protein Glu108-Leu261, with an N-terminal Met

source short :

E. coli

USD :

408 USD

alt names :

CD154, CD154 antigen, CD40 antigen ligand, CD40 ligand, CD40L, CD40-L, CD40LG, CD40LIGM, gp39, hCD40L, HIGM1, T-B cell-activating molecule, T-BAM, T-cell antigen Gp39, TNF-related activation protein, TNFSF5, TNFSF5IMD3, TRAP, TRAPtumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome), tumor necrosis factor (ligand) superfamily member 5, Tumor necrosis factor ligand superfamily member 5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 3 months, 2 to 8 ░C under sterile conditions after reconstitution.