Recombinant Human IL-8/CXCL8 (Endothelial Cell Derived) | R&D Systems 618-IL-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-8/CXCL8 (Endothelial Cell Derived)

catalog :

618-IL-010

quantity :

10 ug (also 50 ug)

price :

181 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Fang K, Law I, Padua D, Sideri A, Huang V, Kevil C, et al. MicroRNA-31-3p Is Involved in Substance P (SP)-Associated Inflammation in Human Colonic Epithelial Cells and Experimental Colitis. Am J Pathol. 2018;188:586-599 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Brown C, Vishwanath R, Aguilar B, Starr R, Najbauer J, Aboody K, et al. Tumor-derived chemokine MCP-1/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells. J Immunol. 2007;179:3332-41 pubmed
Kamohara H, Ogawa M, Ishiko T, Sakamoto K, Baba H. Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression. Int J Oncol. 2007;30:977-83 pubmed
Fan X, Patera A, Pong Kennedy A, Deno G, Gonsiorek W, Manfra D, et al. Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. J Biol Chem. 2007;282:11658-66 pubmed
Olivotto E, Vitellozzi R, Fernandez P, Falcieri E, Battistelli M, Burattini S, et al. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. J Cell Physiol. 2007;210:417-27 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

618-IL

SKU :

618-IL-010

product name :

Recombinant Human IL-8/CXCL8 (Endothelial Cell Derived)

Description :

The Recombinant Human IL-8/CXCL8 (Endothelial Cell Derived) from R&D Systems is derived from E. coli. The Recombinant Human IL-8/CXCL8 (Endothelial Cell Derived) has been validated for the following applications: Bioactivity.

target :

IL-8/CXCL8

category :

Proteins and Enzymes

unit size :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

8.9 kDa

gene symbol :

IL8

details of functionality :

Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils. Schröder, J.M. et al . (1987) J. Immunol. 139 :3474. The ED50 for this effect is 0.2-0.4 µg/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR2. The ED50 for this effect is 1-5 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P10145

applications :

Bioactivity

source :

E. coli-derived Recombinant Human IL-8/CXCL8 (Endothelial Cell Derived)

USD :

181 USD

alt names :

3-10C, AMCF-I, C-X-C motif chemokine 8, CXCL8, CXCL8SCYB8, Emoctakin, GCP1, GCP-1TSG-1, IL8, interleukin 8, K60, LAI, LECT, LUCT, LYNAP, MDNCF, MDNCFb-ENAP, member 8, MONAP, MONAPGCP1, NAF, NAP1, NAP-1NAP1, NCF, Neutrophil-activating protein 1, Protein 3-10C, T cell chemotactic factor, T-cell chemotactic factor, TCF, TSG1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage