product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Wnt-11 Protein
catalog :
6179-WN-010
quantity :
10 ug
price :
601 USD
more info or order :
R&D Systems product webpage
citations: 17
Reference
Heilig A, Nakamura R, Shimada A, Hashimoto Y, Nakamura Y, Wittbrodt J, et al. Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis. elife. 2022;11: pubmed publisher
Świerczek Lasek B, Dudka D, Bauer D, Czajkowski T, Ilach K, Stremińska W, et al. Comparison of Differentiation Pattern and WNT/SHH Signaling in Pluripotent Stem Cells Cultured under Different Conditions. Cells. 2021;10: pubmed publisher
Arisan E, Rencüzoğulları Ö, Cieza Borrella C, Miralles Arenas F, Dwek M, Lange S, et al. MiR-21 Is Required for the Epithelial-Mesenchymal Transition in MDA-MB-231 Breast Cancer Cells. Int J Mol Sci. 2021;22: pubmed publisher
B xf6 ttcher A, B xfc ttner M, Tritschler S, Sterr M, Aliluev A, Oppenl xe4 nder L, et al. Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates. Nat Cell Biol. 2021;23:23-31 pubmed publisher
Rodriguez Hernandez I, Maiques O, Kohlhammer L, Cantelli G, Perdrix Rosell A, Monger J, et al. WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion. Nat Commun. 2020;11:5315 pubmed publisher
Liang W, Han P, Kim E, Mak J, Zhang R, Torrente A, et al. Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells. Stem Cells. 2020;38:352-368 pubmed publisher
Andersen P, Tampakakis E, Jimenez D, Kannan S, Miyamoto M, Shin H, et al. Precardiac organoids form two heart fields via Bmp/Wnt signaling. Nat Commun. 2018;9:3140 pubmed publisher
Boyan B, Olivares Navarrete R, Berger M, Hyzy S, Schwartz Z. Role of Wnt11 during Osteogenic Differentiation of Human Mesenchymal Stem Cells on Microstructured Titanium Surfaces. Sci Rep. 2018;8:8588 pubmed publisher
Reichman D, Park L, Man L, Redmond D, Chao K, Harvey R, et al. Wnt inhibition promotes vascular specification of embryonic cardiac progenitors. Development. 2018;145: pubmed publisher
Touma M, Kang X, Gao F, Zhao Y, Cass A, Biniwale R, et al. Wnt11 regulates cardiac chamber development and disease during perinatal maturation. JCI Insight. 2017;2: pubmed publisher
Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, et al. Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways. Development. 2017;144:1712-1724 pubmed publisher
Rapp J, Kiss E, Meggyes M, Szabó Meleg E, Feller D, Smuk G, et al. Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility. BMC Cancer. 2016;16:915 pubmed
Kilander M, Dahlström J, Schulte G. Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity. Cell Signal. 2014;26:1943-9 pubmed publisher
Keats E, Dominguez J, Grant M, Khan Z. Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis. Stem Cells. 2014;32:1649-60 pubmed publisher
Thrasivoulou C, Millar M, Ahmed A. Activation of intracellular calcium by multiple Wnt ligands and translocation of ?-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/?-catenin pathways. J Biol Chem. 2013;288:35651-9 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Cohen E, Miller M, Wang Z, Moon R, Morrisey E. Wnt5a and Wnt11 are essential for second heart field progenitor development. Development. 2012;139:1931-40 pubmed publisher
product information
brand :
R&D Systems
master code :
6179-WN
SKU :
6179-WN-010
product name :
Recombinant Human Wnt-11 Protein
description :
The Recombinant Human Wnt-11 Protein from R&D Systems is derived from CHO. The Recombinant Human Wnt-11 Protein has been validated for the following applications: Bioactivity.
target :
Wnt-11
category :
Proteins and Enzymes
sizes available :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
38-40 kDa, reducing conditions
theoretical molecular weight :
36.6 kDa
gene symbol :
WNT11
details of functionality :
Measured in a cell proliferation/survival assay using IEC-18 rat small intestinal epithelial cells. The ED50 for this effect is 0.6-2.4 µg/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_004617
applications :
Bioactivity
source :
CHO-derived Recombinant Human Wnt-11 Protein
USD :
572
USD 2023 :
601 USD
alt names :
HWNT11, MGC141946, MGC141948, protein Wnt-11, wingless-type MMTV integration site family, member 11, Wnt11
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.