Recombinant Human Wnt-11 Protein, CF | R&D Systems 6179-WN-010/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Wnt-11 Protein, CF

catalog :

6179-WN-010/CF

quantity :

10 ug

price :

682 USD

citations: 18

Reference
Salerno N, Marino F, Scalise M, Salerno L, Molinaro C, Filardo A, et al. Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice. Mech Ageing Dev. 2022;208:111740 pubmed publisher
Heilig A, Nakamura R, Shimada A, Hashimoto Y, Nakamura Y, Wittbrodt J, et al. Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis. elife. 2022;11: pubmed publisher
Świerczek Lasek B, Dudka D, Bauer D, Czajkowski T, Ilach K, Stremińska W, et al. Comparison of Differentiation Pattern and WNT/SHH Signaling in Pluripotent Stem Cells Cultured under Different Conditions. Cells. 2021;10: pubmed publisher
Arisan E, Rencüzoğulları Ö, Cieza Borrella C, Miralles Arenas F, Dwek M, Lange S, et al. MiR-21 Is Required for the Epithelial-Mesenchymal Transition in MDA-MB-231 Breast Cancer Cells. Int J Mol Sci. 2021;22: pubmed publisher
B xf6 ttcher A, B xfc ttner M, Tritschler S, Sterr M, Aliluev A, Oppenl xe4 nder L, et al. Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates. Nat Cell Biol. 2021;23:23-31 pubmed publisher
Rodriguez Hernandez I, Maiques O, Kohlhammer L, Cantelli G, Perdrix Rosell A, Monger J, et al. WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion. Nat Commun. 2020;11:5315 pubmed publisher
Liang W, Han P, Kim E, Mak J, Zhang R, Torrente A, et al. Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells. Stem Cells. 2020;38:352-368 pubmed publisher
Andersen P, Tampakakis E, Jimenez D, Kannan S, Miyamoto M, Shin H, et al. Precardiac organoids form two heart fields via Bmp/Wnt signaling. Nat Commun. 2018;9:3140 pubmed publisher
Boyan B, Olivares Navarrete R, Berger M, Hyzy S, Schwartz Z. Role of Wnt11 during Osteogenic Differentiation of Human Mesenchymal Stem Cells on Microstructured Titanium Surfaces. Sci Rep. 2018;8:8588 pubmed publisher
Reichman D, Park L, Man L, Redmond D, Chao K, Harvey R, et al. Wnt inhibition promotes vascular specification of embryonic cardiac progenitors. Development. 2018;145: pubmed publisher
Touma M, Kang X, Gao F, Zhao Y, Cass A, Biniwale R, et al. Wnt11 regulates cardiac chamber development and disease during perinatal maturation. JCI Insight. 2017;2: pubmed publisher
Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, et al. Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways. Development. 2017;144:1712-1724 pubmed publisher
Rapp J, Kiss E, Meggyes M, Szabó Meleg E, Feller D, Smuk G, et al. Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility. BMC Cancer. 2016;16:915 pubmed
Kilander M, Dahlström J, Schulte G. Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity. Cell Signal. 2014;26:1943-9 pubmed publisher
Keats E, Dominguez J, Grant M, Khan Z. Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis. Stem Cells. 2014;32:1649-60 pubmed publisher
Thrasivoulou C, Millar M, Ahmed A. Activation of intracellular calcium by multiple Wnt ligands and translocation of ?-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/?-catenin pathways. J Biol Chem. 2013;288:35651-9 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Cohen E, Miller M, Wang Z, Moon R, Morrisey E. Wnt5a and Wnt11 are essential for second heart field progenitor development. Development. 2012;139:1931-40 pubmed publisher

product information

master code :

6179-WN/CF

SKU :

6179-WN-010/CF

product name :

Recombinant Human Wnt-11 Protein, CF

unit size :

10 ug

description :

The Recombinant Human Wnt-11 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Wnt-11 Protein, CF has been validated for the following applications: Bioactivity.

target :

Wnt-11

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS, EDTA and CHAPS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

38-40 kDa, reducing conditions

theoretical molecular weight :

36.6 kDa

gene symbol :

WNT11

details of functionality :

Measured in a cell proliferation/survival assay using IEC-18 rat small intestinal epithelial cells. The ED50 for this effect is 0.6-2.4 ╡g/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_004617

applications :

Bioactivity

source long :

Chinese Hamster Ovary cell line, CHO-derived human Wnt-11 protein Ile25-Lys354

source short :

CHO

USD :

682 USD

alt names :

HWNT11, MGC141946, MGC141948, protein Wnt-11, wingless-type MMTV integration site family, member 11, Wnt11

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.