Recombinant Human Frizzled-7 Fc Chimera Protein, CF | R&D Systems 6178-FZ-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Frizzled-7 Fc Chimera Protein, CF

catalog :

6178-FZ-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Chidiac R, Abedin M, Macleod G, Yang A, Thibeault P, Blazer L, et al. A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Mol Med. 2021;13:e13977 pubmed publisher
Zhang Z, Gao S, Xu Y, Zhao C. Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells. Mol Med Rep. 2021;23: pubmed publisher
Shimizu T, Smits R, Ikenaka K. Microglia-induced activation of non-canonical Wnt signaling aggravates neurodegeneration in demyelinating disorders. Mol Cell Biol. 2016;36:2728-2741 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

6178-FZ

SKU :

6178-FZ-050

product name :

Recombinant Human Frizzled-7 Fc Chimera Protein, CF

Description :

The Recombinant Human Frizzled-7 Fc Chimera Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Frizzled-7 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Frizzled-7

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

55-66 kDa, reducing conditions

theoretical molecular weight :

43.3 kDa (monomer)

gene symbol :

FZD7

details of functionality :

Measured by its binding ability in a functional ELISA. In a 100 µL reaction mixture containing biotinylated rmWnt-5a at 100 ng/mL and rhFrizzled-7/Fc Chimera dilutions at 0.1-8,000 ng/mL, the concentration of rhFrizzled-7/Fc Chimera that produces 50% of the optimal binding response is found to be approximately 20-80 ng/mL. Optimal concentrations should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_003498

applications :

Bioactivity

source :

CHO-derived Recombinant Human Frizzled-7 Fc Chimera Protein

USD :

423 USD

alt names :

frizzled (Drosophila) homolog 7, frizzled homolog 7 (Drosophila), Frizzled, drosophila, homolog of, 7, Frizzled7, fz-7, FZD7, FzE3frizzled-7, hFz7

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage