Recombinant Human ADAMTS13 (Full Length) Protein, CF | R&D Systems 6156-AD-020 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ADAMTS13 (Full Length) Protein, CF

catalog :

6156-AD-020

quantity :

20 ug

price :

541 USD

citations: 8

Reference
Li D, Cho M, Gonzalez Delgado R, Liang X, Dong J, Cruz M, et al. The effect of ADAMTS13 on graft-versus-host disease. J Cell Mol Med. 2024;28:e18457 pubmed publisher
Madarati H, DeYoung V, Singh K, Sparring T, Kwong A, Fredenburgh J, et al. Optimization of plasma-based BioID identifies plasminogen as a ligand of ADAMTS13. Sci Rep. 2024;14:9073 pubmed publisher
Kong L, Zhang Y, Ning J, Xu C, Wang Z, Yang J, et al. CaMKII orchestrates endoplasmic reticulum stress and apoptosis in doxorubicin-induced cardiotoxicity by regulating the IRE1α/XBP1s pathway. J Cell Mol Med. 2022;26:5303-5314 pubmed publisher
Bi Y, Su J, Zhou S, Zhao Y, Zhang Y, Zhang H, et al. Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases. elife. 2022;11: pubmed publisher
Ito T, Minamitani T, Hayakawa M, Otsubo R, Akiba H, Tsumoto K, et al. Optimization of anti-ADAMTS13 antibodies for the treatment of ADAMTS13-related bleeding disorder in patients receiving circulatory assist device support. Sci Rep. 2021;11:22341 pubmed publisher
Kretz C, Tomberg K, Van Esbroeck A, Yee A, Ginsburg D. High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13. Sci Rep. 2018;8:2788 pubmed publisher
Lee M, Keener J, Xiao J, Long Zheng X, Rodgers G. ADAMTS13 and its variants promote angiogenesis via upregulation of VEGF and VEGFR2. Cell Mol Life Sci. 2015;72:349-56 pubmed publisher
Muroi C, Fujioka M, Mishima K, Irie K, Fujimura Y, Nakano T, et al. Effect of ADAMTS-13 on cerebrovascular microthrombosis and neuronal injury after experimental subarachnoid hemorrhage. J Thromb Haemost. 2014;12:505-14 pubmed publisher

product information

master code :

6156-AD

SKU :

6156-AD-020

product name :

Recombinant Human ADAMTS13 (Full Length) Protein, CF

unit size :

20 ug

description :

The Recombinant Human ADAMTS13 (Full Length) Protein, CF from R&D Systems is derived from CHO. The Recombinant Human ADAMTS13 (Full Length) Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ADAMTS13

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in HEPES and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

160-180 kDa, reducing conditions

theoretical molecular weight :

147 kDa 151 kDa

gene symbol :

ADAMTS13

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, FRETS-VWF73. The specific activity is 10 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q76LX8

applications :

Enzyme Activity

source long :

Chinese Hamster Ovary cell line, CHO-derived human ADAMTS13 protein Gln34-Thr1427, with a C-terminal 10-His tag

source short :

CHO

USD :

541 USD

alt names :

A disintegrin and metalloproteinase with thrombospondin motifs 13, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 13, ADAM metallopeptidase with thrombospondin type 1 motif, 13, ADAM-TS13, ADAMTS-13, DKFZp434C2322, EC 3.4.24.14, EC 3.4.24.82, EC 3.4.24.87, FLJ42993, MGC118899, MGC118900, TTP, TTPADAM-TS 13, vWF-cleaving protease, vWF-CP, vWF-CPC9orf8, VWFCPvon Willebrand factor-cleaving protease

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.