Recombinant Human BMP-5 (CHO-expressed) Protein | R&D Systems 615-BMC-020 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human BMP-5 (CHO-expressed) Protein

catalog :

615-BMC-020

quantity :

20 ug

price :

516 USD

citations: 8

Reference
Jin Y, Park S, Park S, Lee C, Eum D, Shim J, et al. G9a Knockdown Suppresses Cancer Aggressiveness by Facilitating Smad Protein Phosphorylation through Increasing BMP5 Expression in Luminal A Type Breast Cancer. Int J Mol Sci. 2022;23: pubmed publisher
Middleton L, Shen Z, Varma S, Pollack A, Gong X, Zhu S, et al. Genomic analysis of benign prostatic hyperplasia implicates cellular re-landscaping in disease pathogenesis. JCI Insight. 2019;5: pubmed publisher
Steinfeld J, Steinfeld I, Bausch A, Coronato N, Hampel M, Depner H, et al. BMP-induced reprogramming of the neural retina into retinal pigment epithelium requires Wnt signalling. Biol Open. 2017;6:979-992 pubmed publisher
Mann Z, Thiede B, Chang W, Shin J, May Simera H, Lovett M, et al. A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nat Commun. 2014;5:3839 pubmed publisher
Lorda Diez C, Montero J, Choe S, Garcia Porrero J, Hurle J. Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro. J Bone Miner Res. 2014;29:735-48 pubmed publisher
Wu Q, Sun C, Lin H, Babitt J. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE. 2012;7:e46307 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher

product information

master code :

615-BMC

SKU :

615-BMC-020

product name :

Recombinant Human BMP-5 (CHO-expressed) Protein

unit size :

20 ug

description :

The Recombinant Human BMP-5 (CHO-expressed) Protein from R&D Systems is derived from CHO. The Recombinant Human BMP-5 (CHO-expressed) Protein has been validated for the following applications: Bioactivity.

target :

BMP-5

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in HCl with BSA as a carrier protein.

conjugate :

Unconjugated

species :

Human

observed molecular weight :

18-23 kDa, reducing conditions

theoretical molecular weight :

15.6 kDa

gene symbol :

BMP5

details of functionality :

Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 0.2-1.2 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P22003

applications :

Bioactivity

source long :

Chinese Hamster Ovary cell line, CHO-derived human BMP-5 protein Ala317-His454

source short :

CHO

USD :

516 USD

alt names :

BMP5, BMP-5, bone morphogenetic protein 5, MGC34244

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.