Recombinant Mouse EphA7 Fc Chimera Protein, CF | R&D Systems 608-A7-200 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse EphA7 Fc Chimera Protein, CF

catalog :

608-A7-200

quantity :

200 ug

price :

341 USD

more info or order :

R&D Systems product webpage

citations: 16

Reference
Arnold L, Cecchini A, Stark D, Ihnat J, Craigg R, Carter A, et al. EphA7 promotes myogenic differentiation via cell-cell contact. elife. 2020;9: pubmed publisher
Li S, Zhai J, Liu J, Di F, Sun Y, Li W, et al. Erythropoietin-producing hepatocellular A7 triggering ovulation indicates a potential beneficial role for polycystic ovary syndrome. EBioMedicine. 2018;36:539-552 pubmed publisher
Weiss A, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe M, et al. Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme. Development. 2014;141:3420-30 pubmed publisher
Defourny J, Poirrier A, Lallemend F, Mateo Sánchez S, Neef J, Vanderhaeghen P, et al. Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells. Nat Commun. 2013;4:1438 pubmed publisher
Park E, Kim Y, Noh H, Lee H, Yoo S, Park S. EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development. Cell Death Differ. 2013;20:169-80 pubmed publisher
Dewannieux M, Vernochet C, Ribet D, Bartosch B, Cosset F, Heidmann T. The mouse IAPE endogenous retrovirus can infect cells through any of the five GPI-anchored Ephrin A proteins. PLoS Pathog. 2011;7:e1002309 pubmed publisher
Marler K, Poopalasundaram S, Broom E, Wentzel C, Drescher U. Pro-neurotrophins secreted from retinal ganglion cell axons are necessary for ephrinA-p75NTR-mediated axon guidance. Neural Dev. 2010;5:30 pubmed publisher
Genander M, Holmberg J, Frisen J. Ephrins negatively regulate cell proliferation in the epidermis and hair follicle. Stem Cells. 2010;28:1196-205 pubmed publisher
Afshari F, Kwok J, Fawcett J. Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J Neurosci. 2010;30:4246-55 pubmed publisher
Torii M, Hashimoto Torii K, Levitt P, Rakic P. Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature. 2009;461:524-8 pubmed publisher
Lim Y, McLaughlin T, Sung T, Santiago A, Lee K, O Leary D. p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. Neuron. 2008;59:746-58 pubmed publisher
Konstantinova I, Nikolova G, Ohara Imaizumi M, Meda P, Kucera T, Zarbalis K, et al. EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell. 2007;129:359-70 pubmed
Chaudhari A, Mahfouz M, Fialho A, Yamada T, Granja A, Zhu Y, et al. Cupredoxin-cancer interrelationship: azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth. Biochemistry. 2007;46:1799-810 pubmed
Rashid T, Upton A, Blentic A, Ciossek T, Knöll B, Thompson I, et al. Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system. Neuron. 2005;47:57-69 pubmed
Muñoz L, Zayachkivsky A, Kunz R, Hunt J, Wang G, Scott S. Ephrin-A5 inhibits growth of embryonic sensory neurons. Dev Biol. 2005;283:397-408 pubmed
Murai K, Nguyen L, Koolpe M, McLennan R, Krull C, Pasquale E. Targeting the EphA4 receptor in the nervous system with biologically active peptides. Mol Cell Neurosci. 2003;24:1000-11 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

608-A7

SKU :

608-A7-200

product name :

Recombinant Mouse EphA7 Fc Chimera Protein, CF

Description :

The Recombinant Mouse EphA7 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse EphA7 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

EphA7

category :

Proteins and Enzymes

unit size :

200 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

observed molecular weight :

110 kDa, reducing conditions

theoretical molecular weight :

85.7 kDa (monomer)

gene symbol :

Epha7

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse EphA7 Fc Chimera at 2 µg/mL (100 µL/well) can bind recombinant human Ephrin-A4 Fc Chimera with a linear range of 0.16 - 10 ng/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

JC5673

applications :

Binding Activity

source :

NS0-derived Recombinant Mouse EphA7 Fc Chimera Protein

USD :

341 USD

alt names :

Cek11, Ebk, EC 2.7.10, EC 2.7.10.1, EHK3, EHK-3, EK11, EPH homology kinase 3, Eph homology kinase-3, EPH receptor A7, EphA7, EPH-like kinase 11, ephrin type-A receptor 7, HEK11, Mdk1, receptor protein-tyrosine kinase HEK11, tyrosine-protein kinase receptor EHK-3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage