Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF | R&D Systems 602-A1-200 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF

catalog :

602-A1-200

quantity :

200 ug

price :

348 USD

more info or order :

R&D Systems product webpage

citations: 20

Reference
Zhang L, Zhou C, Zhou Y, Zhang W, Hu X, Chen M, et al. P-Y/G@NHs sensitizes non-small cell lung cancer cells to radiotherapy via blockage of the PI3K/AKT signaling pathway. Bioorg Chem. 2023;131:106317 pubmed publisher
Gehring M, Pasquale E. Protein kinase C phosphorylates the EphA2 receptor on serine 892 in the regulatory linker connecting the kinase and SAM domains. Cell Signal. 2020;73:109668 pubmed publisher
Darling T, Mimche P, Bray C, Umaru B, Brady L, Stone C, et al. EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS Pathog. 2020;16:e1008261 pubmed publisher
Laing E, Navaratnarajah C, Cheliout Da Silva S, Petzing S, Xu Y, Sterling S, et al. Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus. Proc Natl Acad Sci U S A. 2019;116:20707-20715 pubmed publisher
Barquilla A, Lamberto I, Noberini R, Heynen Genel S, Brill L, Pasquale E. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell. 2016;27:2757-70 pubmed publisher
Kobayashi H, Saito T, Sato K, Furusawa K, Hosokawa T, Tsutsumi K, et al. Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. J Biol Chem. 2014;289:19627-36 pubmed publisher
Naudin C, Sirvent A, Leroy C, Larive R, Simon V, Pannequin J, et al. SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2. Nat Commun. 2014;5:3159 pubmed publisher
Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, et al. ADAM12-cleaved ephrin-A1 contributes to lung metastasis. Oncogene. 2014;33:2179-90 pubmed publisher
Giorgio C, Hassan Mohamed I, Flammini L, Barocelli E, Incerti M, Lodola A, et al. Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation. PLoS ONE. 2011;6:e18128 pubmed publisher
Dunaway C, Hwang Y, Lindsley C, Cook R, Wu J, Boothby M, et al. Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol Cell Biol. 2011;31:404-16 pubmed publisher
Afshari F, Kwok J, Fawcett J. Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J Neurosci. 2010;30:4246-55 pubmed publisher
Miura K, Nam J, Kojima C, Mochizuki N, Sabe H. EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts. Mol Biol Cell. 2009;20:1949-59 pubmed publisher
Wykosky J, Palma E, Gibo D, Ringler S, Turner C, Debinski W. Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. Oncogene. 2008;27:7260-73 pubmed publisher
Yamashita T, Ohneda K, Nagano M, Miyoshi C, Kaneko N, Miwa Y, et al. Hypoxia-inducible transcription factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin A1. J Biol Chem. 2008;283:18926-36 pubmed publisher
Masuda J, Usui R, Maru Y. Fibronectin type I repeat is a nonactivating ligand for EphA1 and inhibits ATF3-dependent angiogenesis. J Biol Chem. 2008;283:13148-55 pubmed publisher
Hong S, Kang U, Isacson O, Kim K. Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons. J Neurochem. 2008;104:316-24 pubmed
Konstantinova I, Nikolova G, Ohara Imaizumi M, Meda P, Kucera T, Zarbalis K, et al. EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell. 2007;129:359-70 pubmed
Chaudhari A, Mahfouz M, Fialho A, Yamada T, Granja A, Zhu Y, et al. Cupredoxin-cancer interrelationship: azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth. Biochemistry. 2007;46:1799-810 pubmed
Macrae M, Neve R, Rodriguez Viciana P, Haqq C, Yeh J, Chen C, et al. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell. 2005;8:111-8 pubmed
Sharfe N, Freywald A, Toro A, Dadi H, Roifman C. Ephrin stimulation modulates T cell chemotaxis. Eur J Immunol. 2002;32:3745-55 pubmed

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

602-A1

SKU :

602-A1-200

product name :

Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF

description :

The Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Ephrin-A1

unit size :

200 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

50-55 kDa, reducing conditions

theoretical molecular weight :

46.8 kDa (monomer)

gene symbol :

Efna1

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized rmEphA2/Fc Chimera at 2 µg/mL (100 µL/well) can bind rmEphrin-A1 Fc Chimera with a linear range of 0.16-10 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P52793

applications :

Binding Activity

product keywords :

602-A1, rmEphrin-A1/Fc, mEphrin-A1, carrier-free, carrier free, 6O2-A1, 602A1, EphrinA1, Ephrin-A 1, Ephrin A1, Tyrosine Kinase

source :

NS0-derived Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF

USD :

341

USD 2025 :

348 USD

alt names :

B61, ECKLG, EFL1, EFL-1, EFNA1, EPH-related receptor tyrosine kinase ligand 1, ephrin-A1, EphrinA1, EPLG1TNF alpha-induced protein 4, Immediate early response protein B61, LERK1, LERK1LERK-1, ligand of eph-related kinase 1, TNFAIP4B61, Tumor necrosis factor alpha-induced protein 4, tumor necrosis factor, alpha-induced protein 4

more info or order :

R&D Systems product webpage