This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Rat Jagged 1 Fc Chimera Protein, CF
catalog :
599-JG-100
quantity :
100 ug
price :
468 USD
citations: 28
Reference
Thambyrajah R, Maqueda M, Neo W, Imbach K, Guill xe9 n Y, Grases D, et al. Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate. Nat Commun. 2024;15:1604 pubmed publisher
Chen Y, Liao G, Ma T, Li L, Yang J, Shen B, et al. YY1/miR-140-5p/Jagged1/Notch axis mediates cartilage progenitor/stem cells fate reprogramming in knee osteoarthritis. Int Immunopharmacol. 2023;121:110438 pubmed publisher
Won J, Choi J, Jun J. CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation. Nat Commun. 2022;13:3117 pubmed publisher
Cheng Y, Gu W, Zhang G, Guo X. Notch1 activation of Jagged1 contributes to differentiation of mesenchymal stem cells into endothelial cells under cigarette smoke extract exposure. BMC Pulm Med. 2022;22:139 pubmed publisher
Zhang S, Miyakawa A, Wickström M, Dyberg C, Louhivuori L, Varas Godoy M, et al. GIT1 protects against breast cancer growth through negative regulation of Notch. Nat Commun. 2022;13:1537 pubmed publisher
Meng J, Jiang Y, Zhao S, Tao Y, Zhang T, Wang X, et al. Tumor-derived Jagged1 promotes cancer progression through immune evasion. Cell Rep. 2022;38:110492 pubmed publisher
Liu B, Wang D, Xiong T, Liu Y, Jing X, Du J, et al. Inhibition of Notch Signaling Promotes the Differentiation of Epicardial Progenitor Cells into Adipocytes. Stem Cells Int. 2021;2021:8859071 pubmed publisher
González S, Halabi M, Ju D, Tsai M, Deng S. Role of Jagged1-mediated Notch Signaling Activation in the Differentiation and Stratification of the Human Limbal Epithelium. Cells. 2020;9: pubmed publisher
Kakuda S, LoPilato R, Ito A, Haltiwanger R. Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2. J Biol Chem. 2020;295:14710-14722 pubmed publisher
Chung W, Zhou Y, Atfi A, Xu K. Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia. Neoplasia. 2019;21:810-821 pubmed publisher
Lan W, Pan S, Li H, Sun C, Chang X, Lu K, et al. Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats. Stem Cells Int. 2019;2019:8404168 pubmed publisher
Kaylan K, Berg I, Biehl M, Brougham Cook A, Jain I, Jamil S, et al. Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling. elife. 2018;7: pubmed publisher
He Y, Zhang M, Wu Y, Jiang H, Fu H, Cai Y, et al. Aberrant activation of Notch-1 signaling inhibits podocyte restoration after islet transplantation in a rat model of diabetic nephropathy. Cell Death Dis. 2018;9:950 pubmed publisher
Davis Knowlton J, Turner J, Turner A, Damian Loring S, Hagler N, Henderson T, et al. Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling. Lab Invest. 2019;99:290-304 pubmed publisher
Varshney S, Stanley P. Notch Ligand Binding Assay Using Flow Cytometry. Bio Protoc. 2017;7: pubmed publisher
Antfolk D, Sjöqvist M, Cheng F, Isoniemi K, Duran C, Rivero Muller A, et al. Selective regulation of Notch ligands during angiogenesis is mediated by vimentin. Proc Natl Acad Sci U S A. 2017;114:E4574-E4581 pubmed publisher
Ji Y, Chen S, Xiang B, Li Y, Li L, Wang Q. Jagged1/Notch3 Signaling Modulates Hemangioma-Derived Pericyte Proliferation and Maturation. Cell Physiol Biochem. 2016;40:895-907 pubmed
Kim K, Chen C, Alpini G, Lau L. CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB. J Clin Invest. 2015;125:1886-900 pubmed publisher
Chen T, Margariti A, Kelaini S, Cochrane A, Guha S, Hu Y, et al. MicroRNA-199b Modulates Vascular Cell Fate During iPS Cell Differentiation by Targeting the Notch Ligand Jagged1 and Enhancing VEGF Signaling. Stem Cells. 2015;33:1405-18 pubmed publisher
He W, Hu J, Xia Y, Yan R. ?-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins. J Biol Chem. 2014;289:20630-7 pubmed
Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, et al. PKC? regulates Notch receptor routing and activity in a Notch signaling-dependent manner. Cell Res. 2014;24:433-50 pubmed publisher
Boucher J, Harrington A, Rostama B, Lindner V, Liaw L. A receptor-specific function for Notch2 in mediating vascular smooth muscle cell growth arrest through cyclin-dependent kinase inhibitor 1B. Circ Res. 2013;113:975-85 pubmed publisher
Sun F, Mao X, Xie L, Ding M, Shao B, Jin K. Notch1 signaling modulates neuronal progenitor activity in the subventricular zone in response to aging and focal ischemia. Aging Cell. 2013;12:978-87 pubmed publisher
Benner E, Luciano D, Jo R, Abdi K, Paez Gonzalez P, Sheng H, et al. Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature. 2013;497:369-73 pubmed publisher
Oya S, Yoshikawa G, Takai K, Tanaka J, Higashiyama S, Saito N, et al. Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury. Neuroscience. 2009;158:683-92 pubmed publisher
Elkabetz Y, Panagiotakos G, Al Shamy G, Socci N, Tabar V, Studer L. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev. 2008;22:152-65 pubmed publisher
Santos M, Sarmento L, Rebelo M, Doce A, Maillard I, Dumortier A, et al. Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells. Proc Natl Acad Sci U S A. 2007;104:15454-9 pubmed
Salero E, Hatten M. Differentiation of ES cells into cerebellar neurons. Proc Natl Acad Sci U S A. 2007;104:2997-3002 pubmed
product information
master code :
599-JG
SKU :
599-JG-100
product name :
Recombinant Rat Jagged 1 Fc Chimera Protein, CF
unit size :
100 ug
description :
The Recombinant Rat Jagged 1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Rat Jagged 1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
Jagged 1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Rat
observed molecular weight :
180 kDa, reducing conditions
theoretical molecular weight :
141.7 kDa (monomer)
gene symbol :
Jag1
details of functionality :
Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al . (2005) J. Biol. Chem. 280 :15842. The ED50 for this effect is 0.5-2.0 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q63722.2
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived rat Jagged 1 protein Rat Jagged 1 Ser32-Asp1067 with substitutions GGARN56-60AE and DR63-64TLVRPY Accession # Q63722.2 IEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus
source short :
NS0
USD :
468 USD
alt names :
AGS, AHDMGC104644, Alagille syndrome, AWS, CD339, CD339 antigen, HJ1, JAG1, jagged 1, Jagged1, JAGL1, protein jagged-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.