Recombinant Human Frizzled-1 Fc Chimera Protein, CF | R&D Systems 5988-FZ-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Frizzled-1 Fc Chimera Protein, CF

catalog :

5988-FZ-050

quantity :

50 ug

price :

443 USD

more info or order :

R&D Systems product webpage

citations: 2

Reference
Chidiac R, Abedin M, Macleod G, Yang A, Thibeault P, Blazer L, et al. A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Mol Med. 2021;13:e13977 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

5988-FZ

SKU :

5988-FZ-050

product name :

Recombinant Human Frizzled-1 Fc Chimera Protein, CF

description :

The Recombinant Human Frizzled-1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Frizzled-1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Frizzled-1

unit size :

50 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

59-66 kDa, reducing conditions

theoretical molecular weight :

46.2 kDa (monomer)

gene symbol :

FZD1

details of functionality :

Measured by its binding ability in a functional ELISA. In a 100 µL reaction mixture containing biotinylated rmWnt-5a at 100 ng/mL and rhFrizzled-1/Fc Chimera dilutions at 0.1-8,000 ng/mL, the concentration of rhFrizzled-1/Fc Chimera that produces 50% of the optimal binding response is found to be approximately 20-80 ng/mL. Optimal concentrations should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9UP38

applications :

Bioactivity

product keywords :

5988-FZ, rhFrizzled-1/Fc, hFrizzled-1, carrier-free, carrier free, 5988FZ, Frizzled1, Frizzled 1, Frz-1, FZ-1, GPCR, G Protein-Coupled Receptor

source :

NS0-derived Recombinant Human Frizzled-1 Fc Chimera Protein, CF

USD :

434

USD 2025 :

443 USD

alt names :

DKFZp564G072, FLJ95923, frizzled family receptor 1, frizzled homolog 1, frizzled, Drosophila, homolog of, 1, frizzled-1, Frizzled1, fz-1, FZD1, fzE1, hFz1, seven transmembrane spanning receptor, Wnt receptor

more info or order :

R&D Systems product webpage