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company name :
R&D Systems
product type :
protein
product name :
Recombinant Rat Leptin Protein, CF
catalog :
598-LP-01M
quantity :
1 mg (also 5 mg)
price :
249 USD
more info or order :
R&D Systems product webpage
citations: 23
Reference
Li K, Hu L, Li X, Yuan Z, He J, Liu D, et al. Effect of C-reactive protein deficiency on insulin resistance reversal in rats with polycystic ovary syndrome through augmented leptin action. Diabetol Metab Syndr. 2023;15:180 pubmed publisher
Khokhlova A, Myachina T, Butova X, Kochurova A, Polyakova E, Galagudza M, et al. The Acute Effects of Leptin on the Contractility of Isolated Rat Atrial and Ventricular Cardiomyocytes. Int J Mol Sci. 2022;23: pubmed publisher
Polyakova E, Mikhaylov E, Galagudza M, Shlyakhto E. Hyperleptinemia results in systemic inflammation and the exacerbation of ischemia-reperfusion myocardial injury. Heliyon. 2021;7:e08491 pubmed publisher
Liu X, Zheng H. Modulation of Sirt1 and FoxO1 on Hypothalamic Leptin-Mediated Sympathetic Activation and Inflammation in Diet-Induced Obese Rats. J Am Heart Assoc. 2021;10:e020667 pubmed publisher
Chen J, Haase N, Haange S, Sucher R, Münzker J, Jäger E, et al. Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk. Mol Metab. 2021;48:101214 pubmed publisher
Shin A, MohanKumar S, Balasubramanian P, Sirivelu M, Linning K, Woolcock A, et al. Responsiveness of hypothalamo-pituitary-adrenal axis to leptin is impaired in diet-induced obese rats. Nutr Diabetes. 2019;9:10 pubmed publisher
Harris R. Development of leptin resistance in sucrose drinking rats is associated with consuming carbohydrate-containing solutions and not calorie-free sweet solution. Appetite. 2019;132:114-121 pubmed publisher
Murata T, Asanuma K, Ara N, Iijima K, Hatta W, Hamada S, et al. Leptin Aggravates Reflux Esophagitis by Increasing Tissue Levels of Macrophage Migration Inhibitory Factor in Rats. Tohoku J Exp Med. 2018;245:45-53 pubmed publisher
Abraham M, Rasti M, Bauer P, Lam T. Leptin enhances hypothalamic lactate dehydrogenase A (LDHA)-dependent glucose sensing to lower glucose production in high-fat-fed rats. J Biol Chem. 2018;293:4159-4166 pubmed publisher
Han Y, Ma B, Guo S, Yang M, Li L, Wang S, et al. Leptin regulates disc cartilage endplate degeneration and ossification through activation of the MAPK-ERK signalling pathway in vivo and in vitro. J Cell Mol Med. 2018;22:2098-2109 pubmed publisher
Zheng X, Niu S. Leptin-induced basal Akt phosphorylation and its implication in exercise-mediated improvement of insulin sensitivity. Biochem Biophys Res Commun. 2018;496:37-43 pubmed publisher
Vargas V, Gurung S, Grant B, Hyatt K, Singleton K, Myers S, et al. Gestational hypoxia disrupts the neonatal leptin surge and programs hyperphagia and obesity in male offspring in the Sprague-Dawley rat. PLoS ONE. 2017;12:e0185272 pubmed publisher
Luo L, Liu Y, Yuan X, Zhang G, Hou N, Wu X, et al. Leptin Attenuates the Contractile Function of Adult Rat Cardiomyocytes Involved in Oxidative Stress and Autophagy. Acta Cardiol Sin. 2016;32:723-730 pubmed
Harris R, Desai B. Fourth-ventricle leptin infusions dose-dependently activate hypothalamic signal transducer and activator of transcription 3. Am J Physiol Endocrinol Metab. 2016;311:E939-E948 pubmed publisher
Thieme K, Oliveira Souza M. Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor. PLoS ONE. 2015;10:e0122265 pubmed publisher
Jamroz Wisniewska A, Gertler A, Solomon G, Wood M, Whiteman M, Bełtowski J. Leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats: role of nitric oxide and hydrogen sulfide. PLoS ONE. 2014;9:e86744 pubmed publisher
Vaill M, Desai B, Harris R. Blockade of the cerebral aqueduct in rats provides evidence of antagonistic leptin responses in the forebrain and hindbrain. Am J Physiol Endocrinol Metab. 2014;306:E414-23 pubmed publisher
Huang W, Metlakunta A, Dedousis N, Ortmeyer H, Stefanovic Racic M, O Doherty R. Leptin augments the acute suppressive effects of insulin on hepatic very low-density lipoprotein production in rats. Endocrinology. 2009;150:2169-74 pubmed publisher
Garza J, Guo M, Zhang W, Lu X. Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J Biol Chem. 2008;283:18238-47 pubmed publisher
Kitagawa J, Shingai T, Kajii Y, Takahashi Y, Taguchi Y, Matsumoto S. Leptin modulates the response to oleic acid in the pharynx. Neurosci Lett. 2007;423:109-12 pubmed
Buison A, Pellizzon M, Ordiz F, Jen K. Augmenting leptin circadian rhythm following a weight reduction in diet-induced obese rats: short- and long-term effects. Metabolism. 2004;53:782-9 pubmed
Mistrik P, Moreau F, Allen J. BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry. Anal Biochem. 2004;327:271-7 pubmed
Kumano S, Matsumoto H, Takatsu Y, Noguchi J, Kitada C, Ohtaki T. Changes in hypothalamic expression levels of galanin-like peptide in rat and mouse models support that it is a leptin-target peptide. Endocrinology. 2003;144:2634-43 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
598-LP
SKU :
598-LP-01M
product name :
Recombinant Rat Leptin Protein, CF
Description :
The Recombinant Rat Leptin Protein, CF from R&D Systems is derived from E. coli. The Recombinant Rat Leptin Protein, CF has been validated for the following applications: Bioactivity.
target :
Leptin/OB
category :
Proteins and Enzymes
unit size :
1 mg (also 5 mg)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Rat
theoretical molecular weight :
16.2 kDa
gene symbol :
Lep
details of functionality :
Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human Leptin R. The ED50 for this effect is 0.05-0.3 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P50596
applications :
Bioactivity
source :
E. coli-derived Recombinant Rat Leptin Protein
USD :
249 USD
alt names :
FLJ94114, LEP, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), OB, Obese protein, obese, mouse, homolog of, Obesity factor, OBOBS
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.