product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-21R Fc Chimera Protein, CF
catalog :
596-MR-100
quantity :
100 ug
price :
423 USD
more info or order :
citations: 30
Reference
Cortés Selva D, Gibbs L, Ready A, Ekiz H, O Connell R, Rajwa B, et al. Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion. PLoS Pathog. 2021;17:e1009260 pubmed publisher
Latham L, Wikenheiser D, Stumhofer J. ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS. PLoS Pathog. 2020;16:e1008527 pubmed publisher
Wang L, Shen E, Luo L, Rabe H, Wang Q, Yin J, et al. Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2019;29:1848-1861.e6 pubmed publisher
Powell M, Read K, Sreekumar B, Jones D, Oestreich K. IL-12 signaling drives the differentiation and function of a TH1-derived TFH1-like cell population. Sci Rep. 2019;9:13991 pubmed publisher
Park J, Kim S, Choi J, Jung K, Hwang S, Yang S, et al. Interleukin-21-mediated suppression of the Pax3-Id3 pathway exacerbates the development of Sjögren's syndrome via follicular helper T cells. Cytokine. 2020;125:154834 pubmed publisher
Cortés Selva D, Ready A, Gibbs L, Rajwa B, Fairfax K. IL-4 promotes stromal cell expansion and is critical for development of a type-2, but not a type 1 immune response. Eur J Immunol. 2019;49:428-442 pubmed publisher
Cheng Q, Liu J, Pei Y, Zhang Y, Zhou D, Pan W, et al. Neddylation contributes to CD4+ T cell-mediated protective immunity against blood-stage Plasmodium infection. PLoS Pathog. 2018;14:e1007440 pubmed publisher
Johndrow C, Goldberg M, Johnson A, Ng T, Kunnath Velayudhan S, Lauvau G, et al. Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes. J Immunol. 2018;201:3604-3616 pubmed publisher
Valentine K, Davini D, Lawrence T, Mullins G, Manansala M, Al Kuhlani M, et al. CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease. J Immunol. 2018;201:31-40 pubmed publisher
Choi J, Seth A, Kashgarian M, Terrillon S, Fung E, Huang L, et al. Disruption of Pathogenic Cellular Networks by IL-21 Blockade Leads to Disease Amelioration in Murine Lupus. J Immunol. 2017;198:2578-2588 pubmed publisher
Hercor M, Anciaux M, Denanglaire S, Debuisson D, Leo O, Andris F. Antigen-presenting cell-derived IL-6 restricts the expression of GATA3 and IL-4 by follicular helper T cells. J Leukoc Biol. 2017;101:5-14 pubmed publisher
Jang E, Cho W, Oh Y, Cho M, Kim J, Paik D, et al. Splenic Long-Lived Plasma Cells Promote the Development of Follicular Helper T Cells during Autoimmune Responses. J Immunol. 2016;196:1026-35 pubmed publisher
Wikenheiser D, Ghosh D, Kennedy B, Stumhofer J. The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection. J Immunol. 2016;196:778-91 pubmed publisher
Preite S, Baumjohann D, Foglierini M, Basso C, Ronchi F, Fernandez Rodriguez B, et al. Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells. Eur J Immunol. 2015;45:3010-21 pubmed publisher
Giles J, Kashgarian M, Koni P, Shlomchik M. B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus. J Immunol. 2015;195:2571-9 pubmed publisher
Teichmann L, Cullen J, Kashgarian M, Dong C, Craft J, Shlomchik M. Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus. Immunity. 2015;42:552-65 pubmed publisher
Kim Y, Lim H, Jung H, Wetsel R, Chung Y. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. PLoS ONE. 2015;10:e0120294 pubmed publisher
Perez Mazliah D, Ng D, Freitas do Rosario A, McLaughlin S, Mastelic Gavillet B, Sodenkamp J, et al. Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria. PLoS Pathog. 2015;11:e1004715 pubmed publisher
Fairfax K, Everts B, Amiel E, Smith A, Schramm G, Haas H, et al. IL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism. J Immunol. 2015;194:2999-3010 pubmed publisher
Weber J, Fuhrmann F, Feist R, Lahmann A, Al Baz M, Gentz L, et al. ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2. J Exp Med. 2015;212:217-33 pubmed publisher
Beverley P, Ruzsics Z, Hey A, Hutchings C, Boos S, Bolinger B, et al. A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis. J Immunol. 2014;193:2306-16 pubmed publisher
Conter L, Song E, Shlomchik M, Tomayko M. CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence. PLoS ONE. 2014;9:e92009 pubmed publisher
Vogelzang A, McGuire H, Liu S, Gloss B, Mercado K, Earls P, et al. IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells. J Immunol. 2014;192:1404-14 pubmed publisher
Ikeda S, Saijo S, Murayama M, Shimizu K, Akitsu A, Iwakura Y. Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-?-induced Foxp3 expression. J Immunol. 2014;192:1449-58 pubmed publisher
Debuisson D, Mari N, Denanglaire S, Leo O, Andris F. Myor/ABF-1 mRNA [corrected] Expression Marks Follicular Helper T Cells but Is Dispensable for Tfh Cell Differentiation and Function In Vivo. PLoS ONE. 2013;8:e84415 pubmed publisher
Boettler T, Moeckel F, Cheng Y, Heeg M, Salek Ardakani S, Crotty S, et al. OX40 facilitates control of a persistent virus infection. PLoS Pathog. 2012;8:e1002913 pubmed publisher
Weber J, Fuhrmann F, Hutloff A. T-follicular helper cells survive as long-term memory cells. Eur J Immunol. 2012;42:1981-8 pubmed publisher
McGuire H, Vogelzang A, Ma C, Hughes W, Silveira P, Tangye S, et al. A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity. Immunity. 2011;34:602-15 pubmed publisher
Kashiwakuma D, Suto A, Hiramatsu Y, Ikeda K, Takatori H, Suzuki K, et al. B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses. J Immunol. 2010;185:2730-6 pubmed publisher
Poholek A, Hansen K, Hernandez S, Eto D, Chandele A, Weinstein J, et al. In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol. 2010;185:313-26 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
596-MR
SKU :
596-MR-100
product name :
Recombinant Mouse IL-21R Fc Chimera Protein, CF
Description :
The Recombinant Mouse IL-21R Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse IL-21R Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-21R
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
70-80 kDa, reducing conditions
theoretical molecular weight :
51.5 kDa (monomer)
gene symbol :
Il21r
details of functionality :
Measured by its ability to inhibit IL-21-dependent enhancement of IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is 75-500 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q9JHX3
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse IL-21R Fc Chimera Protein
USD :
423 USD
alt names :
CD360, CD360 antigen, IL-21 R, IL-21 receptor, IL21R, IL-21R, interleukin 21 receptor, interleukin-21 receptor, MGC10967, NILR, Novel interleukin receptor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.