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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-21 Protein
catalog :
594-ML-010
quantity :
10 ug (also 25 ug, 100 ug)
price :
401 USD
more info or order :
citations: 52
Reference
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Kim Y, Manara F, Grassmann S, Belcheva K, Reyes K, Kim H, et al. IL-21 Shapes the B Cell Response in a Context-Dependent Manner. bioRxiv. 2024;: pubmed publisher
Cheng Q, Yang X, Zou T, Sun L, Zhang X, Deng L, et al. RACK1 enhances STAT3 stability and promotes T follicular helper cell development and function during blood-stage Plasmodium infection in mice. PLoS Pathog. 2024;20:e1012352 pubmed publisher
Scherlinger M, Li H, Pan W, Li W, Karino K, Vichos T, et al. CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses. Nat Commun. 2024;15:840 pubmed publisher
Gu W, Zhang J, Li Q, Zhang Y, Lin X, Wu B, et al. The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation. Cell Discov. 2023;9:82 pubmed publisher
Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, Gulko P. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603 pubmed publisher
Huang H, Li Y, Zhang G, Ruan G, Zhu Z, Chen W, et al. The RNA-binding protein hnRNP F is required for the germinal center B cell response. Nat Commun. 2023;14:1731 pubmed publisher
Quenum A, Santharam M, Ramanathan S, Ilangumaran S. Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8+ T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation. Int J Mol Sci. 2022;23: pubmed publisher
Mary R, Chalmin F, Accogli T, Bruchard M, Hibos C, Melin J, et al. Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects. Cancer Immunol Res. 2022;10:900-916 pubmed publisher
Zotos D, Quast I, Li Wai Suen C, McKenzie C, Robinson M, Kan A, et al. The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21. Nat Commun. 2021;12:7160 pubmed publisher
Singh A, Dashynam M, Chim B, Escobar T, Liu X, Hu X, et al. Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells. Sci Rep. 2021;11:11498 pubmed publisher
Matsuda M, Doi K, Tsutsumi T, Inaba M, Hamaguchi J, Terada T, et al. Adoptive transfer of type 1 regulatory T cells suppressed the development of airway hyperresponsiveness in ovalbumin-induced airway inflammation model mice. J Pharmacol Sci. 2019;141:139-145 pubmed publisher
Yang X, Zhao J, Duan S, Hou X, Li X, Hu Z, et al. Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriers. Theranostics. 2019;9:4066-4083 pubmed publisher
Yen W, Sharma R, Cols M, Lau C, Chaudhry A, Chowdhury P, et al. Distinct Requirements of CHD4 during B Cell Development and Antibody Response. Cell Rep. 2019;27:1472-1486.e5 pubmed publisher
Amir M, Chaudhari S, Wang R, Campbell S, Mosure S, Chopp L, et al. REV-ERBα Regulates TH17 Cell Development and Autoimmunity. Cell Rep. 2018;25:3733-3749.e8 pubmed publisher
Cheng Q, Liu J, Pei Y, Zhang Y, Zhou D, Pan W, et al. Neddylation contributes to CD4+ T cell-mediated protective immunity against blood-stage Plasmodium infection. PLoS Pathog. 2018;14:e1007440 pubmed publisher
Zwarycz B, Gracz A, Rivera K, Williamson I, Samsa L, Starmer J, et al. IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model. Cell Mol Gastroenterol Hepatol. 2019;7:1-17 pubmed publisher
Ise W, Fujii K, Shiroguchi K, Ito A, Kometani K, Takeda K, et al. T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate. Immunity. 2018;48:702-715.e4 pubmed publisher
Sun B, Zhu L, Tao Y, Sun H, Li Y, Wang P, et al. Characterization and allergic role of IL-33-induced neutrophil polarization. Cell Mol Immunol. 2018;15:782-793 pubmed publisher
Muschaweckh A, Petermann F, Korn T. IL-1? and IL-23 Promote Extrathymic Commitment of CD27+CD122- ?? T Cells to ??T17 Cells. J Immunol. 2017;199:2668-2679 pubmed publisher
Tan L, Han S, Ding S, Xiao W, Ding Y, Qian L, et al. Chitosan nanoparticle-based delivery of fused NKG2D-IL-21 gene suppresses colon cancer growth in mice. Int J Nanomedicine. 2017;12:3095-3107 pubmed publisher
Morita K, Okamura T, Inoue M, Komai T, Teruya S, Iwasaki Y, et al. Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production. Proc Natl Acad Sci U S A. 2016;113:E8131-E8140 pubmed
Teichmann L, Cullen J, Kashgarian M, Dong C, Craft J, Shlomchik M. Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus. Immunity. 2015;42:552-65 pubmed publisher
Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, et al. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol. 2015;16:286-95 pubmed publisher
Beverley P, Ruzsics Z, Hey A, Hutchings C, Boos S, Bolinger B, et al. A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis. J Immunol. 2014;193:2306-16 pubmed publisher
Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J, et al. The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis. J Immunol. 2014;193:130-8 pubmed publisher
Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, et al. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting ROR?t and STAT3. J Immunol. 2014;192:5599-609 pubmed publisher
Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, et al. IL-21 induces IL-22 production in CD4+ T cells. Nat Commun. 2014;5:3753 pubmed publisher
Goenka R, Matthews A, Zhang B, O Neill P, Scholz J, Migone T, et al. Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med. 2014;211:45-56 pubmed publisher
Mastrofrancesco A, Kovacs D, Sarra M, Bastonini E, Cardinali G, Aspite N, et al. Preclinical studies of a specific PPARγ modulator in the control of skin inflammation. J Invest Dermatol. 2014;134:1001-1011 pubmed publisher
Yamane F, Nishikawa Y, Matsui K, Asakura M, Iwasaki E, Watanabe K, et al. CSF-1 receptor-mediated differentiation of a new type of monocytic cell with B cell-stimulating activity: its selective dependence on IL-34. J Leukoc Biol. 2014;95:19-31 pubmed publisher
Hwang I, Hwang K, Park C, Harrison K, Kehrl J. Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS ONE. 2013;8:e60139 pubmed publisher
Sutherland A, Joller N, Michaud M, Liu S, Kuchroo V, Grusby M. IL-21 promotes CD8+ CTL activity via the transcription factor T-bet. J Immunol. 2013;190:3977-84 pubmed publisher
Wan C, Oh J, Li P, West E, Wong E, Andraski A, et al. The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity. 2013;38:514-27 pubmed publisher
Michel M, Pang D, Haque S, Potocnik A, Pennington D, Hayday A. Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells. Proc Natl Acad Sci U S A. 2012;109:17549-54 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Klebanoff C, Gattinoni L, Palmer D, Muranski P, Ji Y, Hinrichs C, et al. Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice. Clin Cancer Res. 2011;17:5343-52 pubmed publisher
Kaplan M, Glosson N, Stritesky G, Yeh N, Kinzfogl J, Rohrabaugh S, et al. STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis. Blood. 2011;117:6198-201 pubmed publisher
Sarra M, Caruso R, Cupi M, Monteleone I, Stolfi C, Campione E, et al. IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-?-dependent epidermal hyperplasia. J Immunol. 2011;186:5435-42 pubmed publisher
Tamagawa Mineoka R, Kishida T, Mazda O, Katoh N. IL-21 reduces immediate hypersensitivity reactions in mouse skin by suppressing mast cell activation or IgE production. J Invest Dermatol. 2011;131:1513-20 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010;84:12703-12 pubmed publisher
Jones G, Stumhofer J, Foster T, Twohig J, Hertzog P, Topley N, et al. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J. 2011;25:409-19 pubmed publisher
Suzuki K, Maruya M, Kawamoto S, Sitnik K, Kitamura H, Agace W, et al. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity. 2010;33:71-83 pubmed publisher
Chen G, Hardy K, Bunting K, Daley S, Ma L, Shannon M. Regulation of the IL-21 gene by the NF-?B transcription factor c-Rel. J Immunol. 2010;185:2350-9 pubmed publisher
Pot C, Jin H, Awasthi A, Liu S, Lai C, Madan R, et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol. 2009;183:797-801 pubmed publisher
McCullar V, Oostendorp R, Panoskaltsis Mortari A, Yun G, Lutz C, Wagner J, et al. Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Exp Hematol. 2008;36:598-608 pubmed publisher
Hiromura Y, Kishida T, Nakano H, Hama T, Imanishi J, Hisa Y, et al. IL-21 administration into the nostril alleviates murine allergic rhinitis. J Immunol. 2007;179:7157-65 pubmed
Young D, Hegen M, Ma H, Whitters M, Albert L, Lowe L, et al. Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum. 2007;56:1152-63 pubmed
Liu R, Van Kaer L, La Cava A, Price M, Campagnolo D, Collins M, et al. Autoreactive T cells mediate NK cell degeneration in autoimmune disease. J Immunol. 2006;176:5247-54 pubmed
Jungel A, Distler J, Kurowska Stolarska M, Seemayer C, Seibl R, Forster A, et al. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum. 2004;50:1468-76 pubmed
Brady J, Hayakawa Y, Smyth M, Nutt S. IL-21 induces the functional maturation of murine NK cells. J Immunol. 2004;172:2048-58 pubmed
Di Carlo E, Comes A, Orengo A, Rosso O, Meazza R, Musiani P, et al. IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice. J Immunol. 2004;172:1540-7 pubmed
product information
master code :
594-ML
SKU :
594-ML-010
product name :
Recombinant Mouse IL-21 Protein
unit size :
10 ug (also 25 ug, 100 ug)
description :
The Recombinant Mouse IL-21 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-21 Protein has been validated for the following applications: Bioactivity.
target :
IL-21
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
theoretical molecular weight :
14.4 kDa
gene symbol :
Il21
details of functionality :
Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is 3-30 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Mouse IL-21 Protein Bioactivity
accessionNumbers :
Q9ES17.1
applications :
Bioactivity
source long :
E. coli -derived mouse IL-21 protein Pro25-Ser146, with and without an N-terminal Met
source short :
E. coli
USD :
401 USD
alt names :
CVID11, IL21, IL-21Za11interleukin-21, interleukin 21, interleukin-21 isoform, Za11
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.