product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Semaphorin 3A Fc Chimera Protein
catalog :
5926-S3-025
quantity :
25 ug
price :
480 USD
more info or order :
R&D Systems product webpage
citations: 18
Reference
Kurokawa S, Kashimoto M, Hagikura K, Shimodai Yamada S, Otsuka N, Wakamatsu Y, et al. Intravenous Semaphorin 3A Administration Maintains Cardiac Contractility and Improves Electrical Remodeling in a Mouse Model of Isoproterenol-Induced Heart Failure. Int Heart J. 2023;64:453-461 pubmed publisher
Kamei H, Ishii T, Nishii Y. Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement. Sci Rep. 2022;12:9243 pubmed publisher
Moutal A, Martin L, Boinon L, Gomez K, Ran D, Zhou Y, et al. SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia. bioRxiv. 2020;: pubmed publisher
Sang Y, Tsuji K, Inoue Torii A, Fukushima K, Kitamura S, Wada J. Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury. Int J Mol Sci. 2020;21: pubmed publisher
Li S, Karri D, Sanchez Ortiz E, Jaichander P, Bassel Duby R, Liu N, et al. Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells. Dev Cell. 2019;51:89-98.e4 pubmed publisher
Mohan V, Wade S, Sullivan C, Kasten M, Sweetman C, Stewart R, et al. Close Homolog of L1 Regulates Dendritic Spine Density in the Mouse Cerebral Cortex Through Semaphorin 3B. J Neurosci. 2019;39:6233-6250 pubmed publisher
Bajanca F, Gouignard N, Colle C, Parsons M, Mayor R, Theveneau E. In vivo topology converts competition for cell-matrix adhesion into directional migration. Nat Commun. 2019;10:1518 pubmed publisher
Mediero A, Wilder T, Shah L, Cronstein B. Adenosine A2A receptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis. FASEB J. 2018;32:3487-3501 pubmed publisher
Rienks M, Carai P, Bitsch N, Schellings M, Vanhaverbeke M, Verjans J, et al. Sema3A promotes the resolution of cardiac inflammation after myocardial infarction. Basic Res Cardiol. 2017;112:42 pubmed publisher
Hou S, Nilchi L, Li X, Gangaraju S, Jiang S, Aylsworth A, et al. Semaphorin3A elevates vascular permeability and contributes to cerebral ischemia-induced brain damage. Sci Rep. 2015;5:7890 pubmed publisher
Cheadle L, Biederer T. Activity-dependent regulation of dendritic complexity by semaphorin 3A through Farp1. J Neurosci. 2014;34:7999-8009 pubmed publisher
Kobayashi H, Saito T, Sato K, Furusawa K, Hosokawa T, Tsutsumi K, et al. Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. J Biol Chem. 2014;289:19627-36 pubmed publisher
Rehberg K, Kliche S, Madencioglu D, Thiere M, Muller B, Meineke B, et al. The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth. J Neurosci. 2014;34:5342-54 pubmed publisher
Bäumer B, Kurz A, Borrie S, Sickinger S, Dours Zimmermann M, Zimmermann D, et al. Nogo receptor homolog NgR2 expressed in sensory DRG neurons controls epidermal innervation by interaction with Versican. J Neurosci. 2014;34:1633-46 pubmed publisher
Delgoffe G, Woo S, Turnis M, Gravano D, Guy C, Overacre A, et al. Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature. 2013;501:252-6 pubmed publisher
Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H. Osteoprotection by semaphorin 3A. Nature. 2012;485:69-74 pubmed publisher
Chakraborty G, Kumar S, Mishra R, Patil T, Kundu G. Semaphorin 3A suppresses tumor growth and metastasis in mice melanoma model. PLoS ONE. 2012;7:e33633 pubmed publisher
Naska S, Lin D, Miller F, Kaplan D. p75NTR is an obligate signaling receptor required for cues that cause sympathetic neuron growth cone collapse. Mol Cell Neurosci. 2010;45:108-20 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
5926-S3
SKU :
5926-S3-025
product name :
Recombinant Mouse Semaphorin 3A Fc Chimera Protein
description :
The Recombinant Mouse Semaphorin 3A Fc Chimera Protein from R&D Systems is derived from CHO. The Recombinant Mouse Semaphorin 3A Fc Chimera Protein has been validated for the following applications: Bioactivity.
target :
Semaphorin 3A
unit size :
25 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
115-120 kDa, reducing conditions
theoretical molecular weight :
110.1 kDa (monomer)
details of functionality :
Measured by its ability to cause collapse of chick embryonic dorsal root ganglia (DRG) neuron growth cones. 20-60 ng/mL of Recombinant Mouse Semaphorin 3A Fc Chimera causes 50% growth cone collapse in the presence 10 ng/mL Recombinant Human ß-NGF (Catalog # 256-GF ).
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
O08665
applications :
Bioactivity
product keywords :
5926-S3, rmSema3A/Fc, mSema3A,, 5926S3, Semaphorin3A, Sema 3A, Sema3 A
source :
CHO-derived Recombinant Mouse Semaphorin 3A Fc Chimera Protein
USD :
470
USD 2025 :
480 USD
alt names :
(semaphorin) 3A, coll-1, collapsin 1, Hsema-I, Hsema-III, MGC133243, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, Sema III, SEMA1, Sema3A, SEMAD, SEMAIII, SEMAL, semaphorin D, Semaphorin III, semaphorin L, semaphorin-3A, SemD
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.