This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Klotho beta Protein, CF
catalog :
5889-KB
quantity :
50 ug
price :
409 USD
citations: 5
Reference
Li F, Li X, Li Z, Ji W, Lu S, Xia W. βKlotho is identified as a target for theranostics in non-small cell lung cancer. Theranostics. 2019;9:7474-7489 pubmed publisher
Agrawal A, Parlee S, Perez Tilve D, Li P, Pan J, Mroz P, et al. Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity. Mol Metab. 2018;13:45-55 pubmed publisher
Gutknecht M, Geiger J, Joas S, Dörfel D, Salih H, Müller M, et al. The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells. Cell Commun Signal. 2015;13:19 pubmed publisher
Lee D, Li D, Yan Q, Zhu Y, Goodwin B, Calle R, et al. Fibroblast growth factor 21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived (hASC) adipocytes. PLoS ONE. 2014;9:e111767 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
product information
brand :
R&D Systems
master code :
5889-KB
SKU :
5889-KB-050
product name :
Recombinant Human Klotho beta Protein, CF
description :
The Recombinant Human Klotho beta Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Klotho beta Protein, CF has been validated for the following applications: Bioactivity.
target :
Klotho beta
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Supplied as a 0.2 µm filtered solution in PBS, Glycerol and EDTA.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
113 - 125 kDa, reducing conditions
theoretical molecular weight :
110 kDa
gene symbol :
KLB
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human FGF-21 (Catalog # 2539-FG ) is immobilized at 1 µg/mL (100 µL/well), Recombinant Human Klotho beta His-tag (Catalog # 5889-KB) binds with an ED50 of 2.5-20 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
5889-KB
accessionNumbers :
Q86Z14
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human Klotho beta protein Phe53-Leu997, with a C-terminal 10-His tag
2020 USD :
389
2021 USD :
409 USD
alt names :
beta-klotho, betaKlotho, BKL, KLB, klotho beta, klotho beta like, klotho beta-like protein, MGC142213
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after opening.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.