Recombinant Human Klotho beta Protein, CF | R&D Systems 5889-KB-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Klotho beta Protein, CF

catalog :

5889-KB-050

quantity :

50 ug

price :

567 USD

citations: 7

Reference
Jung Y, Lee K, Cho J, Bae D, Jeong B, Jung Y, et al. Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency. Sci Rep. 2023;13:1005 pubmed publisher
Yanucil C, Kentrup D, Li X, Grabner A, Schramm K, Martinez E, et al. FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes. Sci Rep. 2022;12:7326 pubmed publisher
Niu J, Zhao J, Wu J, Qiao G, Gu J, Zhou C, et al. Curtailing FGF19's mitogenicity by suppressing its receptor dimerization ability. Proc Natl Acad Sci U S A. 2020;117:29025-29034 pubmed publisher
Li F, Li X, Li Z, Ji W, Lu S, Xia W. βKlotho is identified as a target for theranostics in non-small cell lung cancer. Theranostics. 2019;9:7474-7489 pubmed publisher
Agrawal A, Parlee S, Perez Tilve D, Li P, Pan J, Mroz P, et al. Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity. Mol Metab. 2018;13:45-55 pubmed publisher
Gutknecht M, Geiger J, Joas S, DÃ¶rfel D, Salih H, MÃ¼ller M, et al. The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells. Cell Commun Signal. 2015;13:19 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher

product information

master code :

5889-KB

SKU :

5889-KB-050

product name :

Recombinant Human Klotho beta Protein, CF

unit size :

50 ug

description :

The Recombinant Human Klotho beta Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Klotho beta Protein, CF has been validated for the following applications: Bioactivity.

target :

Klotho beta

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in PBS, Glycerol and EDTA.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

113 - 125 kDa, reducing conditions

theoretical molecular weight :

110 kDa

gene symbol :

KLB

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human FGF-21 (Catalog # 2539-FG ) is immobilized at 1 ╡g/mL (100 ╡L/well), Recombinant Human Klotho ▀ His-tag (Catalog # 5889-KB) binds with an ED50 of 2.5-20 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q86Z14

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human Klotho beta protein Phe53-Leu997, with a C-terminal 10-His tag

source short :

NS0

USD :

567 USD

alt names :

beta-klotho, betaKlotho, BKL, KLB, klotho beta, klotho beta like, klotho beta-like protein, MGC142213

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after opening.