product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Klotho beta Protein, CF
catalog :
5889-KB-050
quantity :
50 ug
price :
499 USD
more info or order :
R&D Systems product webpage
citations: 5
Reference
Niu J, Zhao J, Wu J, Qiao G, Gu J, Zhou C, et al. Curtailing FGF19's mitogenicity by suppressing its receptor dimerization ability. Proc Natl Acad Sci U S A. 2020;117:29025-29034 pubmed publisher
Li F, Li X, Li Z, Ji W, Lu S, Xia W. βKlotho is identified as a target for theranostics in non-small cell lung cancer. Theranostics. 2019;9:7474-7489 pubmed publisher
Agrawal A, Parlee S, Perez Tilve D, Li P, Pan J, Mroz P, et al. Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity. Mol Metab. 2018;13:45-55 pubmed publisher
Gutknecht M, Geiger J, Joas S, Dörfel D, Salih H, Müller M, et al. The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells. Cell Commun Signal. 2015;13:19 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
image
image 1 :
R&D Systems 5889-KB-050 image 1
product information
brand :
R&D Systems
master code :
5889-KB
SKU :
5889-KB-050
product name :
Recombinant Human Klotho beta Protein, CF
description :
The Recombinant Human Klotho beta Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Klotho beta Protein, CF has been validated for the following applications: Bioactivity.
target :
Klotho beta
category :
Proteins and Enzymes
sizes available :
50 ug
buffer :
Supplied as a 0.2 µm filtered solution in PBS, Glycerol and EDTA.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
113 - 125 kDa, reducing conditions
theoretical molecular weight :
110 kDa
gene symbol :
KLB
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human FGF-21 (Catalog # 2539-FG ) is immobilized at 1 µg/mL (100 µL/well), Recombinant Human Klotho beta His-tag (Catalog # 5889-KB) binds with an ED50 of 2.5-20 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q86Z14
applications :
Bioactivity
source :
NS0-derived Recombinant Human Klotho beta Protein, CF
USD :
475
USD 2023 :
499 USD
alt names :
beta-klotho, betaKlotho, BKL, KLB, klotho beta, klotho beta like, klotho beta-like protein, MGC142213
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.