product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse TGF-beta RI/ALK-5 Fc Chimera Protein, CF
catalog :
587-RIB-050
quantity :
50 ug
price :
456 USD
more info or order :
R&D Systems product webpage
citations: 2
Reference
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Niessen K, Zhang G, Ridgway J, Chen H, Yan M. ALK1 signaling regulates early postnatal lymphatic vessel development. Blood. 2010;115:1654-61 pubmed publisher
product information
master code :
587-RIB
SKU :
587-RIB-050
product name :
Recombinant Mouse TGF-beta RI/ALK-5 Fc Chimera Protein, CF
unit size :
50 ug
description :
The Recombinant Mouse TGF-beta RI/ALK-5 Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Mouse TGF-beta RI/ALK-5 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
TGF-beta RI/ALK-5
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
40-50 kDa, under reducing conditions.
theoretical molecular weight :
37.5 kDa (monomer)
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Mouse Endoglin/CD105 Fc Chimera Protein (Catalog # 1320-EN ) is immobilized at 2.00 ╡g/mL (100 ╡L/well), Recombinant Mouse TGF┐▀ RI/ALK-5 Fc Chimera (Catalog # 587-RIB) binds with an ED50 of 2.00-15.0 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
BAA05023.1
applications :
Bioactivity
source long :
Spodoptera frugiperda , Sf 21 (baculovirus)-derived mouse TGF-beta RI/ALK-5 protein Mouse TGF┐▀ RI (Ala21-Glu121) (Thr22-Glu121) Accession # BAA05023.1 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
source short :
Sf 21 (baculovirus)
USD :
456 USD
alt names :
AAT5, activin A receptor type II-like kinase, 53kD, activin A receptor type II-like kinase, 53kDa, Activin receptor-like kinase 5, ACVRLK4, ALK-5, ALK-5ALK5, EC 2.7.11, EC 2.7.11.30, LDS1A, LDS2A, Serine/threonine-protein kinase receptor R4, SKR4, TbetaR-I, TGFB1R1, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFbetaRI, TGFBR1, TGF-bRI, TGFR-1, transforming growth factor beta receptor I, transforming growth factor, beta receptor 1, transforming growth factor, beta receptor I (activin A receptor type II-likekinase, 53kD), Transforming growth factor-beta receptor type I
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after opening. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.