product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human APRIL/TNFSF13 (HEK293-expressed) Protein
catalog :
5860-AP-010
quantity :
10 ug
price :
400 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Szymula A, Samayoa Reyes G, Ogolla S, Liu B, Li S, George A, et al. Macrophages drive KSHV B cell latency. Cell Rep. 2023;42:112767 pubmed publisher
Chan C, Harley I, Pfluger P, Trompette A, Stankiewicz T, Allen J, et al. A BAFF/APRIL axis regulates obesogenic diet-driven weight gain. Nat Commun. 2021;12:2911 pubmed publisher
Mulazzani M, Huber M, Borchard S, Langer S, Angele B, Schuh E, et al. APRIL and BAFF: novel biomarkers for central nervous system lymphoma. J Hematol Oncol. 2019;12:102 pubmed publisher
Wilson R, Makuch M, Kienzler A, Varley J, Taylor J, Woodhall M, et al. Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica. Brain. 2018;141:1063-1074 pubmed publisher
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
Brach D, Johnston Blackwell D, Drew A, Lingaraj T, Motwani V, Warholic N, et al. EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL. Mol Cancer Ther. 2017;16:2586-2597 pubmed publisher
Saulep Easton D, Vincent F, Quah P, Wei A, Ting S, Croce C, et al. The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells. Leukemia. 2016;30:163-72 pubmed publisher
Mamara A, Germenis A, Kompoti M, Palassopoulou M, Mandala E, Banti A, et al. TACI expression and signaling in chronic lymphocytic leukemia. J Immunol Res. 2015;2015:478753 pubmed publisher
Deknuydt F, Nordstrom T, Riesbeck K. Diversion of the host humoral response: a novel virulence mechanism of Haemophilus influenzae mediated via outer membrane vesicles. J Leukoc Biol. 2014;95:983-91 pubmed publisher
Osório C, Chacón P, White M, Kisiswa L, Wyatt S, Rodríguez Tébar A, et al. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. Mol Cell Neurosci. 2014;59:24-36 pubmed publisher
Tai Y, Landesman Y, Acharya C, Calle Y, Zhong M, Cea M, et al. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia. 2014;28:155-65 pubmed publisher
product information
master code :
5860-AP
SKU :
5860-AP-010
product name :
Recombinant Human APRIL/TNFSF13 (HEK293-expressed) Protein
unit size :
10 ug
description :
The Recombinant Human APRIL/TNFSF13 (HEK293-expressed) Protein from R&D Systems is derived from HEK293. The Recombinant Human APRIL/TNFSF13 (HEK293-expressed) Protein has been validated for the following applications: Bioactivity.
target :
APRIL/TNFSF13
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Tris-HCl and NaCl with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
26 kDa, reducing conditions
theoretical molecular weight :
21.7 kDa
gene symbol :
TNFSF13
details of functionality :
Measured in a cell proliferation assay using anti-IgM stimulated mouse B cells. The ED50 for this effect is 5-25 ng/mL in the presence of goat anti-mouse IgM.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
O75888
applications :
Bioactivity
source long :
Human embryonic kidney cell, HEK293-derived human APRIL/TNFSF13 protein HA (YPYDVPDYA) GCN4-IZ GGGSGGGSGGGS Human April (Ala105-Leu250) Accession # O75888 N-terminus C-terminus
source short :
HEK293
USD :
400 USD
alt names :
A proliferation-inducing ligand, APRILFLJ57090, CD256, CD256 antigen, TALL2, TALL-2, TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1, TNFSF13, TRDL1, TRDL-1, tumor necrosis factor (ligand) superfamily, member 13, tumor necrosis factor ligand superfamily member 13, tumor necrosis factor-like protein ZTNF2, tumor necrosis factor-related death ligand-1, ZTNF2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.