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company name :
R&D Systems
product type :
protein
product name :
Recombinant Rat IFN-gamma Protein, CF
catalog :
585-IF-100/CF
quantity :
100 ug
price :
396 USD
more info or order :
citations: 38
Reference
Perez Serna A, dos Santos R, Ripoll C, Nadal A, Eizirik D, Marroquí L. BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis. Int J Mol Sci. 2023;24: pubmed publisher
Badia Soteras A, de Vries J, Dykstra W, Broersen L, Verkuyl J, Smit A, et al. High-Throughput Analysis of Astrocyte Cultures Shows Prevention of Reactive Astrogliosis by the Multi-Nutrient Combination Fortasyn Connect. Cells. 2022;11: pubmed publisher
Kim S, Son Y. Astrocytes Stimulate Microglial Proliferation and M2 Polarization In Vitro through Crosstalk between Astrocytes and Microglia. Int J Mol Sci. 2021;22: pubmed publisher
Javeed N, Her T, Brown M, Vanderboom P, Rakshit K, Egan A, et al. Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes. Cell Rep. 2021;36:109613 pubmed publisher
Pusic K, Kraig R, Pusic A. IFNγ-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytes. PLoS ONE. 2021;16:e0255778 pubmed publisher
Wang Y, Sangare L, Paredes Santos T, Hassan M, Krishnamurthy S, Furuta A, et al. Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages. Nat Commun. 2020;11:5258 pubmed publisher
Vig S, Buitinga M, Rondas D, Crèvecoeur I, van Zandvoort M, Waelkens E, et al. Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells. Cell Death Dis. 2019;10:309 pubmed publisher
Lively S, Schlichter L. Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10). Front Cell Neurosci. 2018;12:215 pubmed publisher
Nardelli T, Vanzela E, Benedicto K, Brozzi F, Fujita A, Cardozo A, et al. Prolactin protects against cytokine-induced beta-cell death by NF?B and JNK inhibition. J Mol Endocrinol. 2018;61:25-36 pubmed publisher
Erkens T, Goeminne N, Kegels A, Byloos M, Vinken P. Analytical performance of a commercial multiplex Luminex-based cytokine panel in the rat. J Pharmacol Toxicol Methods. 2018;91:43-49 pubmed publisher
Lambelet M, Terra L, Fukaya M, Meyerovich K, Labriola L, Cardozo A, et al. Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis. Cell Death Dis. 2018;9:96 pubmed publisher
Lim J, Chung E, Son Y. A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFNγ. Sci Rep. 2017;7:9417 pubmed publisher
Clark A, Kanekura K, Lavagnino Z, Spears L, Abreu D, Mahadevan J, et al. Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death. Sci Rep. 2017;7:5611 pubmed publisher
Cunha D, Cito M, Grieco F, Cosentino C, Danilova T, Ladriere L, et al. Pancreatic ?-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF). J Biol Chem. 2017;292:14977-14988 pubmed publisher
Stojadinovic O, Wikramanayake T, Villasante Fricke A, Yin N, Liang L, Hinde E, et al. Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1?-mediated signaling. Heliyon. 2017;3:e00309 pubmed publisher
Cambier L, de Couto G, Ibrahim A, Echavez A, Valle J, Liu W, et al. Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL-10 expression and secretion. EMBO Mol Med. 2017;9:337-352 pubmed publisher
Brozzi F, Gerlo S, Grieco F, Juusola M, Balhuizen A, Lievens S, et al. Ubiquitin D Regulates IRE1?/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells. J Biol Chem. 2016;291:12040-56 pubmed publisher
Marroquin Belaunzaran O, Kleber S, Schauer S, Hausmann M, Nicholls F, Van Den Broek M, et al. HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats. PLoS ONE. 2015;10:e0130811 pubmed publisher
Miljković D, Blaževski J, Petković F, Djedović N, Momčilović M, Stanisavljević S, et al. A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate. J Immunol. 2015;194:2493-503 pubmed publisher
Backe M, Novotny G, Christensen D, Grunnet L, Mandrup Poulsen T. Altering β-cell number through stable alteration of miR-21 and miR-34a expression. Islets. 2014;6:e27754 pubmed publisher
Lazzaro M, Bettegazzi B, Barbariga M, Codazzi F, Zacchetti D, Alessio M. Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microglia. J Neuroinflammation. 2014;11:164 pubmed publisher
Salzano S, Checconi P, Hanschmann E, Lillig C, Bowler L, Chan P, et al. Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal. Proc Natl Acad Sci U S A. 2014;111:12157-62 pubmed publisher
Dahllöf M, Christensen D, Harving M, Wagner B, Mandrup Poulsen T, Lundh M. HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent. J Interferon Cytokine Res. 2015;35:63-70 pubmed publisher
Brozzi F, Gerlo S, Grieco F, Nardelli T, Lievens S, Gysemans C, et al. A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells. J Biol Chem. 2014;289:20677-93 pubmed
Marroquí L, Santin I, dos Santos R, Marselli L, Marchetti P, Eizirik D. BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic ?-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2. Diabetes. 2014;63:2516-27 pubmed publisher
Steelman A, Smith R, Welsh C, Li J. Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem. 2013;288:23776-87 pubmed publisher
Weaver J, Taylor Fishwick D. Regulation of NOX-1 expression in beta cells: a positive feedback loop involving the Src-kinase signaling pathway. Mol Cell Endocrinol. 2013;369:35-41 pubmed publisher
Quan Y, Jiang J, Dingledine R. EP2 receptor signaling pathways regulate classical activation of microglia. J Biol Chem. 2013;288:9293-302 pubmed publisher
Santin I, Moore F, Grieco F, Marchetti P, Brancolini C, Eizirik D. USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis. Cell Death Dis. 2012;3:e419 pubmed publisher
Moore F, Naamane N, Colli M, Bouckenooghe T, Ortis F, Gurzov E, et al. STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. J Biol Chem. 2011;286:929-41 pubmed publisher
Schwarznau A, Hanson M, Sperger J, Schram B, Danobeitia J, Greenwood K, et al. IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis. J Cell Physiol. 2009;220:341-7 pubmed publisher
Husberg C, Nygard S, Finsen A, Damas J, Frigessi A, Oie E, et al. Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure. J Mol Cell Cardiol. 2008;45:261-9 pubmed publisher
Paintlia A, Paintlia M, Singh A, Singh I. Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Mol Pharmacol. 2008;73:1381-93 pubmed publisher
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Frewert S, Stockhammer F, Warschewske G, Zenclussen A, Rupprecht S, Volk H, et al. Intratumoral infusion of interleukin-1beta and interferon-gamma induces tumor invasion with macrophages and lymphocytes in a rat glioma model. Neurosci Lett. 2004;364:145-8 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
585-IF/CF
SKU :
585-IF-100/CF
product name :
Recombinant Rat IFN-gamma Protein, CF
Description :
The Recombinant Rat IFN-gamma Protein, CF from R&D Systems is derived from E. coli. The Recombinant Rat IFN-gamma Protein, CF has been validated for the following applications: Bioactivity.
target :
IFN-gamma
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Supplied as a 0.2 µm filtered solution in Tris, NaCl and PEG 3350.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Rat
theoretical molecular weight :
15.5 kDa
gene symbol :
Ifng
details of functionality :
Measured in an anti-viral assay using L-929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. Meager, A. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 129. The ED50 for this effect is 0.1-0.6 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P01581
applications :
Bioactivity
source :
E. coli-derived Recombinant Rat IFN-gamma Protein
USD :
396 USD
alt names :
IFG, IFI, IFNG, IFNgamma, IFN-gamma, Immune interferon, interferon gamma, interferon, gamma
storage :
3 months from date of receipt, 2 to 8 °C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.