product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant A. caninum NIF Protein, CF
catalog :
5845-NF-050
quantity :
50 ug
price :
541 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Mackey Alfonso S, Butler M, Taylor A, Williams Medina A, Muscat S, Fu H, et al. Short-term high fat diet impairs memory, exacerbates the neuroimmune response, and evokes synaptic degradation via a complement-dependent mechanism in a mouse model of Alzheimer's disease. Brain Behav Immun. 2024;121:56-69 pubmed publisher
Kirkland J, Edgar E, Patel I, Kopec A. Impaired microglia-mediated synaptic pruning in the nucleus accumbens during adolescence results in persistent dysregulation of familiar, but not novel social interactions in sex-specific ways. bioRxiv. 2023;: pubmed publisher
Kopec A, Smith C, Ayre N, Sweat S, Bilbo S. Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats. Nat Commun. 2018;9:3769 pubmed publisher
Wolf D, Anto Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann J, et al. A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Nat Commun. 2018;9:525 pubmed publisher
product information
master code :
5845-NF
SKU :
5845-NF-050
product name :
Recombinant A. caninum NIF Protein, CF
unit size :
50 ug
description :
The Recombinant A. caninum NIF Protein, CF from R&D Systems is derived from NS0. The Recombinant A. caninum NIF Protein, CF has been validated for the following applications: Bioactivity.
target :
NIF
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS, NaCl, and DTT.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
A. caninum
observed molecular weight :
55-65 kDa, reducing conditions
theoretical molecular weight :
30 kDa
details of functionality :
Measured by its ability to inhibit the adhesion of PMA-activated human neutrophils. The ED50 for this effect is 0.1-0.4 ╡g/mL. Also measured by its ability to bind Recombinant Human Integrin alpha M▀2 (Catalog # 4047-AM ) in a functional ELISA.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
AAA27789
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived a. caninum NIF protein Asn18-Leu274, with a C-terminal 6-His tag
source short :
NS0
USD :
541 USD
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.