This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-22 Protein, CF
catalog :
582-ML-010/CF
quantity :
10 ug
price :
425 USD
citations: 32
Reference
Zhou J, Yue J, Yao Y, Hou P, Zhang T, Zhang Q, et al. Dihydromyricetin Protects Intestinal Barrier Integrity by Promoting IL-22 Expression in ILC3s through the AMPK/SIRT3/STAT3 Signaling Pathway. Nutrients. 2023;15: pubmed publisher
Abdallah F, Henriet E, Suet A, Arar A, Clemençon R, Malinge J, et al. miR-21-3p/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response. Cells. 2021;10: pubmed publisher
Zhang J, Wu J, Sun M, Zhang S, Huang J, Man M, et al. Phospholipase C epsilon mediates cytokine cascade induced by acute disruption of epidermal permeability barrier in mice. Biochem Biophys Rep. 2020;24:100869 pubmed publisher
Chen J, Haller C, Jernigan F, Koerner S, Wong D, Wang Y, et al. Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists. Sci Adv. 2020;6:eaay8230 pubmed publisher
Cataisson C, Salcedo R, Michalowski A, Klosterman M, Naik S, Li L, et al. T cell deletion of MyD88 connects IL-17 and IkBz to RAS oncogenesis. Mol Cancer Res. 2019;: pubmed publisher
Katsura H, Kobayashi Y, Tata P, Hogan B. IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration. Stem Cell Reports. 2019;12:657-666 pubmed publisher
Zha J, Li H, Lin Q, Kuo W, Jiang Z, Tsai P, et al. Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling. Cell Mol Gastroenterol Hepatol. 2019;7:255-274 pubmed publisher
Zwarycz B, Gracz A, Rivera K, Williamson I, Samsa L, Starmer J, et al. IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model. Cell Mol Gastroenterol Hepatol. 2019;7:1-17 pubmed publisher
Zhang F, Ledue O, Jun M, Goulart C, Malley R, Lu Y. Protection against Staphylococcus aureus Colonization and Infection by B- and T-Cell-Mediated Mechanisms. MBio. 2018;9: pubmed publisher
Wu J, Gu J, Zhou S, Lu H, Lu Y, Lu L, et al. Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function. J Immunol Res. 2018;2018:1605341 pubmed publisher
Lopes N, Vachon H, Marie J, Irla M. Administration of RANKL boosts thymic regeneration upon bone marrow transplantation. EMBO Mol Med. 2017;9:835-851 pubmed publisher
Ni Y, Huo L, Li T. Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22. World J Gastroenterol. 2017;23:2002-2011 pubmed publisher
Treerat P, Prince O, Cruz Lagunas A, Muñoz Torrico M, Salazar Lezama M, Selman M, et al. Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection. Mucosal Immunol. 2017;10:1069-1081 pubmed publisher
Gray J, Oehrle K, Worthen G, Alenghat T, Whitsett J, Deshmukh H. Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection. Sci Transl Med. 2017;9: pubmed publisher
Erdmann H, Behrends J, Holscher C. During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection. Sci Rep. 2016;6:32927 pubmed publisher
Bergstrom K, Morampudi V, Chan J, Bhinder G, Lau J, Yang H, et al. Goblet Cell Derived RELM-β Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation. PLoS Pathog. 2015;11:e1005108 pubmed publisher
Muñoz M, Eidenschenk C, Ota N, Wong K, Lohmann U, Kühl A, et al. Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection. Immunity. 2015;42:321-331 pubmed publisher
Wang X, Ota N, Manzanillo P, Kates L, Zavala Solorio J, Eidenschenk C, et al. Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes. Nature. 2014;514:237-41 pubmed publisher
Rabeony H, Petit Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, et al. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1?, TNF? and oncostatin M. PLoS ONE. 2014;9:e101937 pubmed publisher
Farin H, Karthaus W, Kujala P, Rakhshandehroo M, Schwank G, Vries R, et al. Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-?. J Exp Med. 2014;211:1393-405 pubmed publisher
Mear J, Gosset P, Kipnis E, Faure E, Dessein R, Jawhara S, et al. Candida albicans airway exposure primes the lung innate immune response against Pseudomonas aeruginosa infection through innate lymphoid cell recruitment and interleukin-22-associated mucosal response. Infect Immun. 2014;82:306-15 pubmed publisher
Turner J, Stockinger B, Helmby H. IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection. PLoS Pathog. 2013;9:e1003698 pubmed publisher
Natividad J, Hayes C, Motta J, Jury J, Galipeau H, Philip V, et al. Differential induction of antimicrobial REGIII by the intestinal microbiota and Bifidobacterium breve NCC2950. Appl Environ Microbiol. 2013;79:7745-54 pubmed publisher
Li Z, Burns A, Miller S, Smith C. CCL20, ?? T cells, and IL-22 in corneal epithelial healing. FASEB J. 2011;25:2659-68 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010;84:12703-12 pubmed publisher
Blumberg H, Dinh H, Dean C, Trueblood E, Bailey K, Shows D, et al. IL-1RL2 and its ligands contribute to the cytokine network in psoriasis. J Immunol. 2010;185:4354-62 pubmed publisher
De Luca A, Zelante T, D Angelo C, Zagarella S, Fallarino F, Spreca A, et al. IL-22 defines a novel immune pathway of antifungal resistance. Mucosal Immunol. 2010;3:361-73 pubmed publisher
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, et al. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis. J Immunol. 2010;184:5263-5270 pubmed publisher
Aujla S, Chan Y, Zheng M, Fei M, Askew D, Pociask D, et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med. 2008;14:275-81 pubmed publisher
Wolk K, Witte E, Hoffmann U, Doecke W, Endesfelder S, Asadullah K, et al. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J Immunol. 2007;178:5973-81 pubmed
Wolk K, Witte E, Wallace E, Döcke W, Kunz S, Asadullah K, et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol. 2006;36:1309-23 pubmed
Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R. IL-22 increases the innate immunity of tissues. Immunity. 2004;21:241-54 pubmed
product information
master code :
582-ML/CF
SKU :
582-ML-010/CF
product name :
Recombinant Mouse IL-22 Protein, CF
unit size :
10 ug
description :
The Recombinant Mouse IL-22 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse IL-22 Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-22
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
theoretical molecular weight :
16.5 kDa
gene symbol :
Il22
details of functionality :
Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. Nagalakshmi, M.L. et al . (2004) International Immunopharmacology 4 :679. The ED50 for this effect is 60-300 pg/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q9JJY9
applications :
Bioactivity
source long :
E. coli -derived mouse IL-22 protein Leu34-Val179, with an N-terminal Met
source short :
E. coli
USD :
425 USD
alt names :
Cytokine Zcyto18, IL-10-related T-cell-derived inducible factor, IL22, IL-D110, IL-TIF, ILTIFIL-10-related T-cell-derived-inducible factor, IL-TIFMGC79382, interleukin 22, interleukin-22, MGC79384, TIFa, TIFIL-23, zcyto18
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.