Recombinant Mouse Siglec-E Fc Chimera Protein, CF | R&D Systems 5806-SL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Siglec-E Fc Chimera Protein, CF

catalog :

5806-SL-050

quantity :

50 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Borges T, Lima K, Murshid A, Lape I, Zhao Y, Rigo M, et al. Innate extracellular Hsp70 inflammatory properties are mediated by the interaction of Siglec-E and LOX-1 receptors. bioRxiv. 2023;: pubmed publisher
Egan H, Treacy O, Lynch K, Leonard N, O Malley G, Reidy E, et al. Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment. Cell Rep. 2023;42:112475 pubmed publisher
Pluvinage J, Haney M, Smith B, Sun J, Iram T, Bonanno L, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. 2019;568:187-192 pubmed publisher
Hsu F, Belmonte P, Constans M, Chen M, McWilliams D, Hiebert S, et al. Histone Deacetylase 3 Is Required for T Cell Maturation. J Immunol. 2015;195:1578-90 pubmed publisher
Chen G, Brown N, Wu W, Khedri Z, Yu H, Chen X, et al. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. elife. 2014;3:e04066 pubmed publisher

product information

brand :

R&D Systems

master code :

5806-SL

SKU :

5806-SL-050

product name :

Recombinant Mouse Siglec-E Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Mouse Siglec-E Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Siglec-E Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Siglec-E

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

75-95 kDa, reducing conditions

theoretical molecular weight :

64.6 kDa (monomer)

gene symbol :

Siglece

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Mouse Siglec-E Fc Chimera is immobilized at 2 ╡g/mL (100 ╡L/well), it binds to Recombinant Mouse Galectin-3 (HEK293-expressed) Protein (Catalog # 9039-GAB ) with an ED50 of 0.08-0.8 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Mouse Siglec-E Fc Chimera Protein Binding Activity

accessionNumbers :

AAH23280

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse Siglec-E Fc Chimera Protein, CF

USD :

456 USD

alt names :

CD170;CD33L2;OBBP2;OB-BP2;Sialic acid-binding Ig-like lectin 5;SIGLEC5;SIGLEC-5, SiglecE

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage