Recombinant Rat TIMP-1 Protein, CF | R&D Systems 580-RT-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Rat TIMP-1 Protein, CF

catalog :

580-RT-010

quantity :

10 ug

price :

516 USD

citations: 5

Reference
Sanz R, Ferraro G, Girouard M, Fournier A. Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons. Sci Rep. 2017;7:7961 pubmed publisher
FjÃ¦re E, Andersen C, Myrmel L, Petersen R, Hansen J, Tastesen H, et al. Tissue Inhibitor Of Matrix Metalloproteinase-1 Is Required for High-Fat Diet-Induced Glucose Intolerance and Hepatic Steatosis in Mice. PLoS ONE. 2015;10:e0132910 pubmed publisher
Ramezani Moghadam M, Wang J, Ho V, Iseli T, Alzahrani B, Xu A, et al. Adiponectin reduces hepatic stellate cell migration by promoting tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion. J Biol Chem. 2015;290:5533-42 pubmed publisher
Sanz R, Ferraro G, Fournier A. IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth. J Biol Chem. 2015;290:4330-42 pubmed publisher
Birukawa N, Murase K, Sato Y, Kosaka A, Yoneda A, Nishita H, et al. Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth. J Biol Chem. 2014;289:20209-21 pubmed publisher

product information

master code :

580-RT

SKU :

580-RT-010

product name :

Recombinant Rat TIMP-1 Protein, CF

unit size :

10 ug

description :

The Recombinant Rat TIMP-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Rat TIMP-1 Protein, CF has been validated for the following applications: Inhibition Activity.

target :

TIMP-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Rat

observed molecular weight :

32-34 kDa, reducing conditions

theoretical molecular weight :

21.5 kDa

gene symbol :

Timp1

details of functionality :

Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The IC50 value is 3.0 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P30120

applications :

Inhibition Activity

source long :

Mouse myeloma cell line, NS0-derived rat TIMP-1 protein Cys24-Ala217

source short :

NS0

USD :

516 USD

alt names :

CLGI, Collagenase inhibitor, collagenase inhibitor), EPATIMP-1, EPO, erythroid potentiating activity, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, FLJ90373, HCI, metalloproteinase inhibitor 1, TIMP metallopeptidase inhibitor 1, TIMP1, TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, Tissue inhibitor of metalloproteinases 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.