Recombinant Rat Neuropilin-1 Fc Chimera Protein, CF | R&D Systems 566-N1-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Rat Neuropilin-1 Fc Chimera Protein, CF

catalog :

566-N1-025

quantity :

25 ug

price :

468 USD

citations: 6

Reference
Tymecka D, LipiÅ„ski P, Fedorczyk B, Puszko A, WileÅ„ska B, Perret G, et al. Structure-activity relationship study of tetrapeptide inhibitors of the Vascular Endothelial Growth Factor A binding to Neuropilin-1. Peptides. 2017;94:25-32 pubmed publisher
Teran M, Nugent M. Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity. J Biol Chem. 2015;290:16451-62 pubmed publisher
Harris N, Davydova N, Roufail S, Paquet Fifield S, Paavonen K, Karnezis T, et al. The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology. J Biol Chem. 2013;288:8176-86 pubmed publisher
Lake A, Vassy R, Di Benedetto M, Lavigne D, Le Visage C, Perret G, et al. Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1. J Biol Chem. 2006;281:37844-52 pubmed
Tokunaga Y, Yamazaki Y, Morita T. Localization of heparin- and neuropilin-1-recognition sites of viral VEGFs. Biochem Biophys Res Commun. 2006;348:957-62 pubmed
Narazaki M, Tosato G. Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A. Blood. 2006;107:3892-901 pubmed

product information

master code :

566-N1

SKU :

566-N1-025

product name :

Recombinant Rat Neuropilin-1 Fc Chimera Protein, CF

unit size :

25 ug

description :

The Recombinant Rat Neuropilin-1 Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Rat Neuropilin-1 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Neuropilin-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Citrate Phosphate and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Rat

observed molecular weight :

130-150 kDa, reducing conditions

theoretical molecular weight :

119 kDa (monomer)

gene symbol :

Nrp1

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized rrNeuropilin-1/Fc Chimera can bind rhVEGF165 with an apparent KDá á1ánM.

endotoxin note :

<0.1 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9QWJ9

applications :

Binding Activity

source long :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived rat Neuropilin-1 protein Rat Neuropilin-1 Phe22 - Asp854 (Lys811Arg and Pro812 - Gly828 del) Accession # Q9QWJ9 IEGRDMD Human IgG1 (Pro100 - Lys330) 6-His tag N-terminus C-terminus

source short :

Sf 21 (baculovirus)

USD :

468 USD

alt names :

BDCA4, BDCA-4, CD304, CD304 antigen, DKFZp686A03134, DKFZp781F1414, neuropilin 1, neuropilin-1, Neuropilin1, NP1, NRP, NRP1, transmembrane receptor, Vascular endothelial cell growth factor 165 receptor, VEGF165R

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.