product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human FOLR1 Protein, CF
catalog :
5646-FR-050
quantity :
50 ug
price :
443 USD
more info or order :
R&D Systems product webpage
citations: 6
Reference
Spicer J, Basu B, Montes A, Banerji U, Kristeleit R, Miller R, et al. Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial. Nat Commun. 2023;14:4180 pubmed publisher
Bax H, Chauhan J, Stavraka C, Santaolalla A, Osborn G, Khiabany A, et al. Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes. Br J Cancer. 2023;128:342-353 pubmed publisher
Song J, Sokoll L, Chan D, Zhang Z. Validation of Serum Biomarkers That Complement CA19-9 in Detecting Early Pancreatic Cancer Using Electrochemiluminescent-Based Multiplex Immunoassays. Biomedicines. 2021;9: pubmed publisher
Correa I, Ilieva K, Crescioli S, Lombardi S, Figini M, Cheung A, et al. Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells. Front Immunol. 2018;9:493 pubmed publisher
Kelemen L, Brenton J, Parkinson C, C Whitaker H, Piskorz A, Csizmadi I, et al. Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women. PLoS ONE. 2014;9:e96542 pubmed publisher
Rudman S, Josephs D, Cambrook H, Karagiannis P, Gilbert A, Dodev T, et al. Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of Fc?RI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity. Clin Exp Allergy. 2011;41:1400-13 pubmed publisher
product information
master code :
5646-FR
SKU :
5646-FR-050
product name :
Recombinant Human FOLR1 Protein, CF
unit size :
50 ug
description :
The Recombinant Human FOLR1 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human FOLR1 Protein, CF has been validated for the following applications: Binding Activity.
target :
FOLR1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
30-40 kDa, reducing conditions
theoretical molecular weight :
25.4 kDa
gene symbol :
FOLR1
details of functionality :
Measured by its binding ability in a functional ELISA. When Folic Acid-Bovine Serum Albumin is coated at 5 ╡g/mL (100 ╡L/well), the concentration of rhFOLR-1 that produces 50% of the optimal binding response is found to be approximately 0.4 -1.6 nM.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P15328
applications :
Binding Activity
source long :
Chinese Hamster Ovary cell line, CHO-derived human FOLR1 protein Arg25-Met233, with a C-terminal 6x-His tag
source short :
CHO
USD :
443 USD
alt names :
Adult folate-binding protein, FBP, folate binding protein, Folate receptor 1, folate receptor 1 (adult), folate receptor alpha, Folate receptor, adult, Folbp1, FOLR, FR-alpha, KB cells FBP, MOv18, Ovarian tumor-associated antigen MOv18
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.