This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse TSLP Protein
catalog :
555-TS-010
quantity :
10 ug
price :
432 USD
citations: 34
Reference
Toyosawa Y, Komiya E, Kaneko T, Suga Y, Tominaga M, Takamori K. Type 2 cytokine-JAK1 signaling is involved in the development of dry skin-induced mechanical alloknesis. J Dermatol Sci. 2025;117:52-60 pubmed publisher
Zhang H, Xue K, Li W, Yang X, Gou Y, Su X, et al. Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity. Nat Commun. 2024;15:252 pubmed publisher
Gurram R, Wei D, Yu Q, Butcher M, Chen X, Cui K, et al. Crosstalk between ILC2s and Th2 cells varies among mouse models. Cell Rep. 2023;42:112073 pubmed publisher
Segaud J, Yao W, Marschall P, Daubeuf F, Lehalle C, Germán B, et al. Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march. Nat Commun. 2022;13:4703 pubmed publisher
Arae K, Ikutani M, Horiguchi K, Yamaguchi S, Okada Y, Sugiyama H, et al. Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin. Sci Rep. 2021;11:5913 pubmed publisher
Ebina Shibuya R, West E, Spolski R, Li P, Oh J, Kazemian M, et al. Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses. elife. 2021;10: pubmed publisher
Baban B, Braun M, Khodadadi H, Ward A, Alverson K, Malik A, et al. AMPK induces regulatory innate lymphoid cells after traumatic brain injury. JCI Insight. 2021;6: pubmed publisher
Yao F, Yuan Q, Song X, Zhou L, Liang G, Jiang G, et al. Yupingfeng Granule Improves Th2-Biased Immune State in Microenvironment of Hepatocellular Carcinoma through TSLP-DC-OX40L Pathway. Evid Based Complement Alternat Med. 2020;2020:1263053 pubmed publisher
Mishra S, Wheeler J, Pitake S, Ding H, Jiang C, Fukuyama T, et al. Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. Cell Rep. 2020;31:107472 pubmed publisher
Li S, Yi Z, Deng M, Scott M, Yang C, Li W, et al. TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway. JCI Insight. 2019;4: pubmed publisher
Ragonnaud E, Moritoh K, Bodogai M, Gusev F, Garaud S, Chen C, et al. Tumor-Derived Thymic Stromal Lymphopoietin Expands Bone Marrow B-cell Precursors in Circulation to Support Metastasis. Cancer Res. 2019;79:5826-5838 pubmed publisher
Han N, Moon P, Kim H, Jeong H. TSLP Exacerbates Septic Inflammation via Murine Double Minute 2 (MDM2) Signaling Pathway. J Clin Med. 2019;8: pubmed publisher
Inagaki Katashiba N, Ito T, Inaba M, Azuma Y, Tanaka A, Phan V, et al. Statins can suppress DC-mediated Th2 responses through the repression of OX40-ligand and CCL17 expression. Eur J Immunol. 2019;49:2051-2062 pubmed publisher
Bernink J, Ohne Y, Teunissen M, Wang J, Wu J, Krabbendam L, et al. c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies. Nat Immunol. 2019;20:992-1003 pubmed publisher
Han M, Rajput C, Hong J, Lei J, Hinde J, Wu Q, et al. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice. J Immunol. 2017;199:1308-1318 pubmed publisher
Kummola L, Ortutay Z, Chen X, Caucheteux S, Hämäläinen S, Aittomäki S, et al. IL-7Rα Expression Regulates Murine Dendritic Cell Sensitivity to Thymic Stromal Lymphopoietin. J Immunol. 2017;198:3909-3918 pubmed publisher
Guo L, Huang Y, Chen X, Hu Li J, Urban J, Paul W. Innate immunological function of TH2 cells in vivo. Nat Immunol. 2015;16:1051-9 pubmed publisher
Duque Afonso J, Feng J, Scherer F, Lin C, Wong S, Wang Z, et al. Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. J Clin Invest. 2015;125:3667-80 pubmed publisher
Ochiai S, Roediger B, Abtin A, Shklovskaya E, Fazekas de St Groth B, Yamane H, et al. CD326(lo)CD103(lo)CD11b(lo) dermal dendritic cells are activated by thymic stromal lymphopoietin during contact sensitization in mice. J Immunol. 2014;193:2504-11 pubmed publisher
Gao Y, Nish S, Jiang R, Hou L, Licona Limón P, Weinstein J, et al. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity. 2013;39:722-32 pubmed publisher
Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, et al. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. J Immunol. 2013;190:3153-62 pubmed publisher
Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, et al. Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. J Immunol. 2012;189:3641-52 pubmed
Fridman J, Scherle P, Collins R, Burn T, Neilan C, Hertel D, et al. Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation. J Invest Dermatol. 2011;131:1838-44 pubmed publisher
Oh M, Oh S, Yu J, Myers A, Leonard W, Liu Y, et al. IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J Immunol. 2011;186:7232-42 pubmed publisher
Jung K, Tanaka A, Fujita H, Matsuda A, Oida K, Karasawa K, et al. Peroxisome proliferator-activated receptor ?-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice. J Allergy Clin Immunol. 2011;127:420-429.e1-6 pubmed publisher
Perrigoue J, Saenz S, Siracusa M, Allenspach E, Taylor B, Giacomin P, et al. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol. 2009;10:697-705 pubmed publisher
Goswami S, Angkasekwinai P, Shan M, Greenlee K, Barranco W, Polikepahad S, et al. Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. Nat Immunol. 2009;10:496-503 pubmed publisher
Headley M, Zhou B, Shih W, Aye T, Comeau M, Ziegler S. TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses. J Immunol. 2009;182:1641-7 pubmed
Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, et al. A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum. 2008;58:3510-9 pubmed publisher
Vang K, Yang J, Mahmud S, Burchill M, Vegoe A, Farrar M. IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J Immunol. 2008;181:3285-90 pubmed
Besin G, Gaudreau S, Ménard M, Guindi C, Dupuis G, Amrani A. Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes. Diabetes. 2008;57:2107-17 pubmed publisher
Sokol C, Barton G, Farr A, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 2008;9:310-8 pubmed publisher
Seshasayee D, Lee W, Zhou M, Shu J, Suto E, Zhang J, et al. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J Clin Invest. 2007;117:3868-78 pubmed
Osborn M, Ryan P, Kirchhof N, Panoskaltsis Mortari A, Mortari F, Tudor K. Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis. Blood. 2004;103:843-51 pubmed
product information
master code :
555-TS
SKU :
555-TS-010
product name :
Recombinant Mouse TSLP Protein
unit size :
10 ug
description :
The Recombinant Mouse TSLP Protein from R&D Systems is derived from NS0. The Recombinant Mouse TSLP Protein has been validated for the following applications: Bioactivity.
target :
TSLP
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
22-29 kDa, reducing conditions
theoretical molecular weight :
15 kDa
gene symbol :
Tslp
details of functionality :
Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with mouse IL-7 R alpha . The ED50 for this effect is 0.5-2.5 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
NP_067342
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived mouse TSLP protein Tyr20-Glu140, with a C-terminal 10-His tag
source short :
NS0
USD :
432 USD
alt names :
thymic stromal lymphopoietin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.