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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-15R alpha Fc Chimera Protein, CF
catalog :
551-MR-100
quantity :
100 ug
price :
432 USD
more info or order :
citations: 41
Reference
Kang S, Mansurov A, Kurtanich T, Chun H, Slezak A, Volpatti L, et al. Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity. Sci Adv. 2023;9:eadh9879 pubmed publisher
Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar O, et al. CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury. JCI Insight. 2023;8: pubmed publisher
Devarajan P, Vong A, Castonguay C, Silverstein N, Kugler Umana O, Bautista B, et al. Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15. Cell Rep. 2023;42:113182 pubmed publisher
Tieniber A, Hanna A, Medina B, Vitiello G, Etherington M, Liu M, et al. Tyrosine Kinase Inhibition Alters Intratumoral CD8+ T-cell Subtype Composition and Activity. Cancer Immunol Res. 2022;10:1210-1223 pubmed publisher
Tao H, Pan Y, Chu S, Li L, Xie J, Wang P, et al. Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals. Nat Commun. 2021;12:2029 pubmed publisher
Ng S, de Labastida Rivera F, Yan J, Corvino D, Das I, Zhang P, et al. The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nat Immunol. 2020;21:1205-1218 pubmed publisher
Sommer C, Cheng H, Nguyen D, Dettling D, Yeung Y, Sutton J, et al. Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery. Mol Ther. 2020;28:2237-2251 pubmed publisher
Yu M, Pan H, Che N, Li L, Wang C, Wang Y, et al. Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells. Cell Mol Immunol. 2020;: pubmed publisher
LUCAS B, White A, Cosway E, Parnell S, James K, Jones N, et al. Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells. Nat Commun. 2020;11:2198 pubmed publisher
Schmid A, Neri D. Design and characterisation of a novel interleukin-15 receptor alpha fusion protein and analysis of interleukin-15 complexation. PLoS ONE. 2019;14:e0219313 pubmed publisher
Alvarez M, Simonetta F, Baker J, Pierini A, Wenokur A, Morrison A, et al. Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathway. JCI Insight. 2019;5: pubmed publisher
Simonović N, Witalisz Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, et al. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity. J Immunol. 2019;202:1724-1734 pubmed publisher
Burrack K, Huggins M, Taras E, Dougherty P, Henzler C, Yang R, et al. Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells. Immunity. 2018;48:760-772.e4 pubmed publisher
Islam S, Choi B, Choi J, Lee E, Sohn S. Frequencies of IL-15R?+ cells in patients with Behçet's disease and the effects of overexpressing IL-15R?+ on disease symptoms in mice. Cytokine. 2018;110:257-266 pubmed publisher
Delong J, Hall A, Konradt C, Coppock G, Park J, Harms Pritchard G, et al. Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1. J Immunol. 2018;200:1761-1770 pubmed publisher
Sowell R, Goldufsky J, Rogozinska M, Quiles Z, Cao Y, Castillo E, et al. IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues. J Immunol. 2017;199:2536-2546 pubmed publisher
Kubo H, Mensurado S, Gonçalves Sousa N, Serre K, Silva Santos B. Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells. Cancer Immunol Res. 2017;5:812-820 pubmed publisher
Kavazović I, Lenartic M, Jelencic V, Jurkovic S, Lemmermann N, Jonjic S, et al. NKG2D stimulation of CD8+ T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice. Eur J Immunol. 2017;47:1123-1135 pubmed publisher
Guo Y, Luan L, Patil N, Wang J, Bohannon J, Rabacal W, et al. IL-15 Enables Septic Shock by Maintaining NK Cell Integrity and Function. J Immunol. 2017;198:1320-1333 pubmed publisher
Patil N, Luan L, Bohannon J, Guo Y, Hernandez A, Fensterheim B, et al. IL-15 Superagonist Expands mCD8+ T, NK and NKT Cells after Burn Injury but Fails to Improve Outcome during Burn Wound Infection. PLoS ONE. 2016;11:e0148452 pubmed publisher
Corpuz T, Stolp J, Kim H, Pinget G, Gray D, Cho J, et al. Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines. J Immunol. 2016;196:645-54 pubmed publisher
Guo Y, Luan L, Rabacal W, Bohannon J, Fensterheim B, Hernandez A, et al. IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ. J Immunol. 2015;195:2353-64 pubmed publisher
Yokota S, Yoshida O, Dou L, Spadaro A, Isse K, Ross M, et al. IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production. J Immunol. 2015;194:6045-56 pubmed publisher
Villanueva J, Malle E, Gardam S, Silveira P, Zammit N, Walters S, et al. TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15. Eur J Immunol. 2015;45:1820-31 pubmed publisher
Nair S, Fang M, Sigal L. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment. Aging Cell. 2015;14:180-90 pubmed publisher
Kurtulus S, Sholl A, Toe J, Tripathi P, Raynor J, Li K, et al. Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins. Cell Death Differ. 2015;22:174-84 pubmed publisher
Cowan J, McCarthy N, Parnell S, White A, Bacon A, Serge A, et al. Differential requirement for CCR4 and CCR7 during the development of innate and adaptive ??T cells in the adult thymus. J Immunol. 2014;193:1204-12 pubmed publisher
White A, Jenkinson W, Cowan J, Parnell S, Bacon A, Jones N, et al. An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells. J Immunol. 2014;192:2659-66 pubmed publisher
Levanon D, Negreanu V, Lotem J, Bone K, Brenner O, Leshkowitz D, et al. Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation. Mol Cell Biol. 2014;34:1158-69 pubmed publisher
Kurtulus S, Tripathi P, Moreno Fernandez M, Sholl A, Katz J, Grimes H, et al. Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim. J Immunol. 2011;186:5729-37 pubmed publisher
Verbist K, Cole C, Field M, Klonowski K. A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection. J Immunol. 2011;186:174-82 pubmed publisher
Castillo E, Acero L, Stonier S, Zhou D, Schluns K. Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation. Blood. 2010;116:2494-503 pubmed publisher
Suwanai H, Wilcox M, Mathis D, Benoist C. A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2010;107:9305-10 pubmed publisher
Johnson L, Jameson S. Self-specific CD8+ T cells maintain a semi-naive state following lymphopenia-induced proliferation. J Immunol. 2010;184:5604-11 pubmed publisher
Pepper M, Linehan J, Pagán A, Zell T, Dileepan T, Cleary P, et al. Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat Immunol. 2010;11:83-9 pubmed publisher
Vang K, Yang J, Mahmud S, Burchill M, Vegoe A, Farrar M. IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J Immunol. 2008;181:3285-90 pubmed
Rubinstein M, Lind N, Purton J, Filippou P, Best J, McGhee P, et al. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood. 2008;112:3704-12 pubmed publisher
Epardaud M, Elpek K, Rubinstein M, Yonekura A, Bellemare Pelletier A, Bronson R, et al. Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells. Cancer Res. 2008;68:2972-83 pubmed publisher
Hart G, Avin Wittenberg T, Shachar I. IL-15 regulates immature B-cell homing in an Ly49D-, IL-12 , and IL-18 dependent manner. Blood. 2008;111:50-9 pubmed
Rafei M, Wu J, Annabi B, Lejeune L, Francois M, Galipeau J. A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood. 2007;109:2234-42 pubmed
Rhodes K, Raivich G, Fawcett J. The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience. 2006;140:87-100 pubmed
product information
brand :
R&D Systems
master code :
551-MR
SKU :
551-MR-100
product name :
Recombinant Mouse IL-15R alpha Fc Chimera Protein, CF
unit size :
100 ug
seo description :
The Recombinant Mouse IL-15R alpha Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse IL-15R alpha Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-15R alpha
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
observed molecular weight :
80-90 kDa, 42 kDa and 35 kDa, reducing conditions
theoretical molecular weight :
44.9 kDa (monomer)
gene symbol :
Il15ra
details of functionality :
Measured by its ability to block human IL-15-induced proliferation of CTLL-2 mouse cytotoxic T cells. Ruchatz,áH. etáal . (1998) J.áImmunol. 160 :5654. The ED50 for this effect is 0.1-0.5 ng/mL in the presence of 0.1 ng/mL recombinant human IL-15.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q60819
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse IL-15R alpha Fc Chimera Protein, CF
USD :
432 USD
alt names :
CD215, CD215 antigen, IL15 R alpha, IL-15 R alpha, IL-15 receptor subunit alpha, IL15RA, IL-15RA, IL-15R-alpha, interleukin 15 receptor, alpha, interleukin-15 receptor subunit alpha, MGC104179
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.