Recombinant Human Integrin alpha 6 (X1) beta 4 Protein, CF | R&D Systems 5497-A6 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Integrin alpha 6 (X1) beta 4 Protein, CF

catalog :

5497-A6

quantity :

50 ug

price :

389 USD

citations: 4

Reference
Rajan A, Persson B, Frängsmyr L, Olofsson A, Sandblad L, Heino J, et al. Enteric Species F Human Adenoviruses use Laminin-Binding Integrins as Co-Receptors for Infection of Ht-29 Cells. Sci Rep. 2018;8:10019 pubmed publisher
Russo V, Klein T, Lim D, Solis N, Machado Y, Hiroyasu S, et al. Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction. Sci Rep. 2018;8:9690 pubmed publisher
Florea F, Bernards C, Caproni M, Kleindienst J, Hashimoto T, Koch M, et al. Ex vivo pathogenicity of anti-laminin ?1 autoantibodies. Am J Pathol. 2014;184:494-506 pubmed publisher
Chong B, Tseng L, Lee T, Vasquez R, Li Q, Zhang S, et al. IgG and IgM autoantibody differences in discoid and systemic lupus patients. J Invest Dermatol. 2012;132:2770-9 pubmed publisher

product information

brand :

R&D Systems

master code :

5497-A6

SKU :

5497-A6-050

product name :

Recombinant Human Integrin alpha 6 (X1) beta 4 Protein, CF

description :

The Recombinant Human Integrin alpha 6 (X1) beta 4 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Integrin alpha 6 (X1) beta 4 Protein, CF has been validated for the following applications: Bioactivity.

target :

Integrin alpha 6 beta 4

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

125-135 kDa ( alpha 6) 100-110 kDa ( beta 4), reducing conditions

theoretical molecular weight :

104 kDa ( alpha 6) 84.8 kDa ( beta 4)

gene symbol :

ITGA6

details of functionality :

Measured by its binding ability in a functional ELISA. When Mouse Laminin I (Catalog # 3400-010-01 ) is coated at 10 µg/mL, Recombinant Human Integrin alpha 6 beta 4 binds with an apparent KD 5 nM.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

5497-A6

accessionNumbers :

NP_000201 (Integrin alpha 6) P16144 (Integrin beta 4)

applications :

Bioactivity

source :

Chinese Hamster Ovary cell line, CHO-derived human Integrin alpha 6 beta 4 protein Human Integrin alpha 6 (Phe24-Lys878) Accession # NP_000201 Acidic Tail HHHHHH Human Integrin beta 4 (Asn28-Ser710) Accession # P16144 Basic Tail N-terminus C-terminus

2020 USD :

389

2021 USD :

389 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.